【摘要】 目的 观察氧化苦参碱注射液治疗慢性重度乙型肝炎的临床疗效。方法 将60例慢性重度乙型肝炎患者分为两组:治疗组30例，用氧化苦参碱注射液600mg静脉滴注；对照组30例，以阿拓莫兰1.2g静脉滴注，疗程8周，治疗前后检测肝功能、乙型肝炎病毒复制标志物HBV DNA和HBeAg，同时观察患者的症状、体征的变化及药物的不良反应。结果 HBV复制指标HBeAg、HBV DNA的转阴率治疗组明显高于对照组，差异有显著性(P<0.05)。治疗结束后AST、ALT、TBIL治疗组明显低于对照组，差异有显著性(P<0.05)。结论 氧化苦参碱对乙型肝炎病毒有抑制作用，是治疗慢性乙型肝炎较为有效的中药制剂。

     【关键词】 氧化苦参碱；慢性乙型肝炎；抗病毒

    Therapeutic effect of oxymatrine on patients with chronic hepatitis B

    HE Chang-dong，HOU Zhou-hua，LI Guo-tao.Infectious Diseases Department，People’s Hospital of Jiahe，Jiahe 424500，China

    【Abstract】 Objective To observe the clinical effect and adverse effect of oxymatrine in treating patients with chronic hepatitis B.Methods 60 patients with chronic hepatitis B were randomly divided into two groups，the control group (n=30) was only received liver-protective drugs and supportive therapy ......