奥氮平与氯氮平治疗难治性精神分裂症对照研究
难治性精神分裂症；奥氮平；氯氮平；对照研究,,难治性精神分裂症；奥氮平；氯氮平；对照研究,【摘要】,【关键词】,1资料与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨奥氮平治疗难治性精神分裂症的疗效和安全性。 方法 将43例难治性精神分裂症患者随机分为奥氮平治疗组(研究组，21例)和氯氮平治疗组(对照组，22例)，于治疗前和治疗第1、2、4、8、12w末采用阳性与阴性症状量表评定临床疗效，副反应量表评定不良反应，并进行对比分析。 结果 治疗前两组阳性与阴性症状量表各项得分无显著差异(P>0.05)；治疗后两组总有效率无显著性差异(P>0.05)；认知因子和阴性症状减分率，两组间有显著差异性(P<0.05或P<0.01)；奥氮平的不良反应较氯氮平轻。 结论 奥氮平对难治性精神分裂症疗效肯定，不良反应较轻，特别是在改善认知功能和阴性症状方面有较好的效果。【关键词】 难治性精神分裂症；奥氮平；氯氮平；对照研究
A controlled study of olanzapine and clozapine in refractory schizophrenia
Yang Lishen , Li Zhengcai，Wang Weisheng, et al
(Yunnan mental health center, Anning 650301, Yunnan, China)
【Abstract】 Objective To explore the curative effect and safety of olanzapine in refractory schizophrenia. Methods 43 patients with refractory schizophrenia were randomly divided into research group (olanzapine, n=21) and controlled group (clozapine, n=22). Effectiveness and safety were assessed by the PANSS and Treatment Emergent Symptoms Scale(TESS) before treatment and at the ends of week 1,2,4,8 and 12,respectively. Results There were no significant differences in scores of the Positive and Negative Symptoms Scal(PANSS) before treatment and in total effective rates after treatment between two groups( both P>0.05); there were significant differences in cognitive factor and scorereducing rates of negative symptoms(P<0.05 or 0.01). The side effects of olanzapine were milder than that of clozapine. Conclusion Olanzapine is effective and has milder side effects in the treatment of refractory schizophrenia, especially in improving cognitive function and negative symptoms. ......
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