利培酮与氯氮平对首发精神分裂症患者血脂的影响
精神分裂症；利培酮；氯氮平；血脂,,精神分裂症；利培酮；氯氮平；血脂,【摘要】,【关键词】,1对象与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨利培酮与氯氮平对首发精神分裂症患者血脂的影响。 方法 将118例首发精神分裂症患者随机分为利培酮组58例，氯氮平组60例，于治疗前及治疗第4、8、12w末晨间空腹采血，并进行血脂检测比较。用药剂量根据病情加减，但2w内应加至有效治疗量。 结果 氯氮平组8w末血脂显著上升，12w末稍有下降；利培酮组4w末血脂稍有升高，第8、12w末无显著变化。 结论 利培酮与氯氮平对首发精神分裂症患者血脂均有影响，但利培酮影响较轻。【关键词】 精神分裂症；利培酮；氯氮平；血脂
Effects of risperidone vs clozapine on bloodlipid of firstepisode schizophrenia
Zhou Bao, Tang Yin, Zhu Liwen
(Ninxia mental health center,Lingwu 750401, Ninxia, China)
【Abstract】 Objective To explore the effects of risperidone vs clozapine on bloodlipid of firstepisode schizophrenia. Methods 118 firstepisode schizophrenics were randomly divided into the risperidone group(n=58) and clozapine group(n=60), fasting bloods in the early morning were took before treatment and at the ends of 4th, 8th and 12th week of treatment to compare the bloodlipid. Dosage was increased or decreased according to patients' condition, but should be added to effective therapeutic dose within 2 weeks. Results The bloodlipids rose at the end of 8th week and slightly dropped at the 12th in the clozapine group; those slightly rose at the end of the 4th week and had no significant changes at the 8th and 12th in the risperidone group. Conclusion Both risperidone and clozapine affects bloodlipid of firstepisode schizophrenia, but effects of the former is milder. ......
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