【摘要】 目的 探讨奎硫平联合牛黄宁宫片治疗精神分裂症的疗效及安全性。 方法 将113例精神分裂症随机分为研究组56例和对照组57例，研究组给予奎硫平联合牛黄宁宫片治疗，对照组单用奎硫平治疗，两组奎硫平平均治疗剂量502.47±75.53mg·d-1，疗程12w。采用简明精神病症状量表、阳性与阴性症状评定量表、总体评定量表和副反应量表于治疗前及治疗第12w末评定临床疗效与不良反应。 结果 12w末研究组痊愈率41.7%，显效率80.4%；对照组痊愈率31.6%，显效率56.1%，两组差异极显著(P<0.01)。研究组起效较对照组快，不良反应差异不显著。 结论 牛黄宁宫片可增强奎硫平对精神分裂症的总体疗效，安全性高，依从性好。

     【关键词】 精神分裂症；奎硫平；牛黄宁宫片

    Comparative analyses of quitiapine combined with Niuhuang Ningong tablet in schizophrenia

    Hao Baoli, Qiu Huimin

    (Licheng District mental health center, Jinan 250112, Shangdong,China)

    【Abstract】 Objective To explore the curative effects and safety of quitiapine combined with Niuhuang Ningong tablet in schizophrenia. Methods 113 schizophrenics were randomly divided into research group( took quitiapine combined with Niuhuang Ningong tablet, n=56) and control group(did quitiapine, n=57) for 12 weeks, the mean dosage of quitiapine was 502.47±75.53mg/d for both the 2 groups. Clinical effectiveness and side effects were assessed with The Brief Psychiatric Rating Scale(BPRS), Positive And Negative Symptom Scale(PANSS), Global Assessment Scale(GAS) and Treatment Emergent Symptom Scale(TESS) before treatment and at the end of 12th week of treatment. Results At the end of 12th week, cure and effectual rates were respectively 41.7% and 80.4% in the research group and 31.3% and 56.1% in the control group, which showed the most significant difference(P<0.01); the research group took faster than the control group did. Difference of the side effect was not significant. Conclusion Niuhuang Ningong tablet could amplify total curative effect of quitiapine in schizophrenia and had higher safety and better compliance. ......