人肝癌组织中PARP-1的表达与生物学特征的关系
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王志强, 黄志勇, 陈孝平, 张志发
聚腺苷二磷酸核糖聚合酶;原发性肝细胞癌;生物学特征;免疫组化;免疫印迹王志强,黄志勇,陈孝平,张志发.人肝癌组织中PARP-1的表达与生物学特征的关系. 世界华人消化杂志2006;14(2
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王志强, 黄志勇, 陈孝平, 张志发, 华中科技大学同济医学院附属同济医院肝脏外科中心 湖北省武汉市 430030
王志强, 华中科技大学同济医学院附属同济医院肝脏外科中心硕士研究生, 主要从事肝脏外科、肝癌发生的分子机制及治疗研究.教育部新世纪优秀人才支持计划项目资助, No. NCET-04-0701
通讯作者: 黄志勇, 430030, 湖北省武汉市解放大道1095号, 华中科技大学同济医学院附属同济医院肝脏外科中心.
zyhuang@medmail.com.cn
电话: 027-83663871 传真: 027-83663400
收稿日期: 2006-05-09 接受日期: 2006-05-25
Relationship between expression of poly adenosine diphosphate-ribose polymerase-1 and its biological characteristics in human hepatocellular carcinoma
Zhi-Qiang Wang, Zhi-Yong Huang, Xiao-Ping Chen, Zhi-Fa Zhang
Zhi-Qiang Wang, Zhi-Yong Huang, Xiao-Ping Chen, Zhi-Fa Zhang, Center of Hepatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Supported by the New Centaury Excellent Talent Foundation from Ministry of Education, No. NCET-04-0701
Correspondence to: Dr. Zhi-Yong Huang, Center of Hepatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. zyhuang@medmail.com.cn
Received: 2006-05-09Accepted: 2006-05-25
AbstractAIM:To investigate the expression of poly adenosine diphosphate-ribose polymerase-1 (PARP-1) in human hepatocellular carcinoma (HCC) and its adjacent liver tissues as well as the correlation between the expression of PARP-1 and the biological characteristics.
METHODS:Immunohistochemical staining and Western blotting were employed to examine the expression of PARP-1 in HCC and its adjacent liver tissues obtained from the surgical specimens of 40 HCC patients who underwent liver resections in our hospital, and the correlation between the expression level of PARP-1 and the differentiation, recurrence and metastasis of HCC were analyzed.
RESULTS:The expression of PARP-1 was mainly located in the nucleus, and the rate of PARP-1 expression in HCC was significantly higher than that in its adjacent liver tissues (t = 6 ......
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