大肠癌IFN-γ基因+874位点的单核苷酸多态性
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费保莹, 吕火祥, 陈永伟, 杨建民
干扰素;大肠肿瘤;多态性费保莹，吕火祥，陈永伟，杨建民.大肠癌IFN-g基因+874位点的单核苷酸多态性. 世界华人消化杂志2006;14(20)2022-2025 IFN-γ
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费保莹, 杨建民, 浙江省人民医院消化内科 浙江省杭州市 310014
吕火祥, 浙江省人民医院检验科 浙江省杭州市 310014
陈永伟, 浙江省人民医院肛肠科 浙江省杭州市 310014浙江省卫生厅科研基金项目, No.97420
通讯作者: 费保莹, 310014, 浙江省杭州市朝晖四区158号, 浙江省人民医院消化内科. feibaoying6924@tom.com
电话: 0571-85893430
收稿日期: 2006-04-20 接受日期: 2006-06-05
Single nucleotide polymorphism of interferon-gamma gene +874 T/A in colorectal cancer
Bao-Ying Fei, Huo-Xiang Lv, Yong-Wei Chen, Jian-Min Yang
Bao-Ying fei, Jian-Min Yang, Department of Gastroenterology, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China
Huo-Xiang Lv, Department of Clinical Laboratory, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China
Yong-Wei Chen, Department of Coloproctology, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China
Supported By the Fund from Health Department of Zhejiang Province, No. 97420
Correspondence to: Dr. Bao-Ying Fei, Department of Gastroenterology, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China. feibaoying6924@tom.com
Received: 2006-04-20 Accepted: 2006-06-05
Abstract
AIM: To investigate whether the single nucleotide polymorphism (SNP) of interferon-gamma (IFN-g) +874 T/A correlates with colorectal cancer in Han Chinese of Zhejiang province, China.
METHODS: The alleles of IFN-g gene were detected in 132 healthy subjects and 92 patients with colorectal cancer using amplification refractory mutation system (ARMS)-PCR. Meanwhile, the PCR products were cloned and sequenced ......
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