【摘要】 目的 探讨不同剂量阿托伐他汀对高龄冠心病患者进行强化降脂治疗的疗效和安全性。方法 选择70例高龄(≥75岁)冠心病患者，随机分为治疗组(阿托伐他汀30mg/d)和对照组(阿托伐他汀10mg/d)，观察患者服药前及服药后12个月血脂、主要不良心血管事件及药物不良作用。结果 阿托伐他汀治疗后，治疗组TC、LDL-C水平与对照组比较显著降低(P<0.01)，且治疗组发生非致死性心肌梗死、不稳定型心绞痛、血管重建、冠心病死亡者较对照组减少，差异有显著性(P<0.05)。治疗组与对照组相比，血ALT轻度升高者增加，但差异无显著性(P>0.05)。结论 对于高龄冠心病患者，阿托伐他汀30mg/d能降低TC、LDL-C水平，明显减少主要心血管事件的发生，不良反应无明显增加。

     【关键词】 阿托伐他汀；冠心病；高龄

    【Abstract】 Objective To evaluate the efficacy and safty of atorvastatin in different dosages for treatment in senile patients with coronary heart disease. Methods 70 patients(≥75years old) with coronary heart diseases were randomized into higher dose group (atorvastatin 30mg/d) and lower dose group (atorvastatin 10mg/d). The levels of TC、LDL-C、TG and HDL-C in serum were examined，and cardiac events and side-effects of atorvastatin were observed before and after atorvastatin therapy. Results After 12 months of treatment，the levels of TC、LDL-C in higher dose group were decreased more remarkedly than in lower dose group (P<0.01).The attacks of non-death myocardial infarction ......