自身免疫性甲状腺疾病；_环境；_碘_

调查研究碘与自身免疫性甲状腺疾病发病的关系

http://www.100md.com 《中华首席医学网》 2006年第3期

自身免疫性甲状腺疾病；,环境；,碘,,自身免疫性甲状腺疾病；,环境；,碘,摘要,关键词,1材料与方法,2结果,3讨论,参考文献

     摘要：目的了解目前陕西地区自身免疫性甲状腺疾病(AITD)患者碘的营养状况，初步探讨人体内碘的代谢状况与AITD发生、发展的关系。方法收集病例388例，其中AITD患者283例，非AITD对照105例。进行问卷调查，了解研究对象的一般情况；记录甲状腺的大小、形态、质地等情况；测定尿碘浓度、甲状腺功能以及甲状腺自身抗体。应用SPSS12.0进行数据处理。结果研究人群中Graves病(GD)组的尿碘中位数是212μg/L，桥本甲状腺炎(HT)组是245.4μg/L，对照组是197.8 μg/ L，三组的尿碘分布有统计学差异。HT组患者在不同的尿碘水平上，血清甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(TMAb)以及高敏促甲状腺激素(HSTSH)水平的差别无统计学差异。结论在AITD患者中存在饮食碘过多的问题，此可能在AITD的发病中起作用。

     关键词：自身免疫性甲状腺疾病；环境；碘

    Clinical research on the relationship between iodine and autoimmunity thyroid disease

    Wu Yueqin, He Lan, Liu Ping, Xu Li

    (Department of Endocrinology, the First Affiliated Hospital, Medical School of Xian Jiaotong University, Xian 710061, China)

    ABSTRACT: Objective To observe the iodine state of patients with autoimmunity thyroid disease(AITD) in Shaanxi province, and to discuss the relationship between the metabolism of iodine and the occurrance, development and prognosis of AITD. Methods A total of 388 cases were collected, among whom 283 were patients with AITD, and 105 were patients with nonAITD. Questionnaires were designed to determine the general state of the patients, the size, shape and texture of the thyroid, the urinary concentration of iodine, the function of thyroid and the autoantibody of thyroid. The data were processed by SPSS12.0. Results The mean urinary concentrations of iodine in patients with GD, with HT, and the control group were 212μg/L, 245.4μg/L, and 197.8μg/L respectively, which were statistically different. In the HT group, wich different urinary concentrations of iodine, there were no statistical difference of TGAb, TMAb, and HSTSH. Conclusion Excessive intake of dietary iodine may be related with AITD. ......

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