E钙黏附素及增殖细胞核抗原在胰腺癌组织中的表达及其意义
E钙黏附素；增殖细胞核抗原；胰腺癌,,E钙黏附素；增殖细胞核抗原；胰腺癌,摘要,关键词,1材料与方法,2结果,3讨论,参考文献
摘要：目的 研究Ecadherin、增殖细胞核抗原(PCNA)在胰腺癌组织中的表达及临床意义。方法 应用免疫组化方法对59例胰腺癌组织的Ecadherin、PCNA进行检测。结果 Ecadherin在胰腺癌组织比相应的癌旁正常胰腺组织中表达明显减低，高表达率仅为13.6%(8/59)，且各组间(与癌组织分化程度、淋巴结转移以及临床分期)Ecadherin表达差异有统计学意义(P<0.05)；PCNA在胰腺癌组织比相应的癌旁正常胰腺组织表达明显增高，强阳性表达率为67.8%(40/59)，且各组间PCNA表达差异有统计学意义(P<0.05)；在胰腺癌组织中，Ecadherin与PCNA表达呈负相关(P<0.05)。结论 Ecadherin与PCNA异常表达与胰腺癌的分化、增殖、侵袭以及转移有密切的关系。关键词：E钙黏附素；增殖细胞核抗原；胰腺癌
Expression of Ecadherin and PCNA in pancreatic adenocarcinoma and their clinic significance
Zhao Jun, Yao Jianfeng, Ma Jiancang, Zhao Guanghui, Luo Liang
(Department of General Surgery, the Second Affiliated Hospital, Medical School of Xian Jiaotong University, Xian710004, China)
ABSTRACT: Objective To study the expression of Ecadherin and PCNA in pancreatic adenocarcinoma and their clinical significance. Methods Ecadherin and PCNA in 59 cases of pancreatic adenocarcinoma was studied by immunohistochemistry. Results The decreased expression of Ecadherin in pancreatic adenocarcinoma was significantly lower than that in normal pancreas; the higher rate of expression only was 13.6%(8/59); and the expression of Ecadherin in various groups was statistically significant with the differentiation of carcinoma; the metastasis of lymph nodes and the clinical stages(P<0.05); the increased expression of PCNA in pancreatic adenocarcinoma was significantly higher than that in normal pancreas; the higher positive rate of PCNA was 67.8%(40/59); and the expression of PCNA in various groups was significant in statistics with the differentiation of carcinoma; the metastasis of lymph nodes and the clinical stages(P<0.05); the correlation between Ecadherin and PCNA was negative in pancreatic adenocarcinoma.(P<0.05). Conclusion The abnormal expression of Ecadherin and PCNA are closely associated with the differentiation, proliferation, invasion and metastasis of pancreatic adenocarcinoma. ......
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