蛋白激酶B丝氨酸磷酸化在非乙醇性脂肪肝发病机制中的作用
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韩继武, 詹晓蓉, 阴惠清, 梁桂敏, 何 强,
非乙醇性脂肪肝;蛋白激酶B;丝氨酸磷酸化;高脂饮食;胰岛素抵抗,韩继武,詹晓蓉,阴惠清,梁桂敏,何强,王月影,通讯作者,Roleofprotei
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韩继武, 哈尔滨医科大学附属第一医院消化科在读博士 黑龙江省哈尔滨市 150001
詹晓蓉, 阴惠清, 梁桂敏, 何强, 王月影, 哈尔滨医科大学附属第一医院内分泌科 黑龙江省哈尔滨市 150001
黑龙江省自然科学基金资助课题, No. 2005-13
通讯作者: 詹晓蓉, 150001, 黑龙江省哈尔滨市南岗区邮政街23号, 哈尔滨医科大学附属第一医院内分泌科.
xiaorongzhan@sina.com
电话: 0451-53643849-5061
收稿日期: 2006-05-13 接受日期: 2006-06-27
Role of protein kinase B serine phosphorylation in pathogenesis of nonalcoholic fatty liver disease induced by high-fat diets
Ji-Wu Han, Xiao-Rong Zhan, Hui-Qing Yin, Gui-Min Liang, Qiang He, Yue-Ying Wang
Ji-Wu Han, Department of Digestive Disease, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Xiao-Rong Zhan, Hui-Qing Yin, Gui-Min Liang, Qiang He, Yue-Ying Wang, Department of Endocrinology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Supported by the Natural Science Foundation of Heilongjiang Province, No. 2005-13
Correspondence to: Xiao-Rong Zhan, Department of Endocrinology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China. xiaorongzhan@sina.com
Received: 2006-05-13 Accepted: 2006-06-27
Abstract
AIM: To clarify whether protein kinase B (PKB) serine phosphorylation pathway is involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) induced by high-fat diets.
METHODS: Sixty male Wistar rats were randomly divided into group A, B and C. The rats in group A served as controls, and those in group B and C were fed with high-fat diets for 16 wk. Meanwhile, the rats in group C were also treated with rosiglitazone 4 mg per day. At the end of 16th wk, all the animals were sacrificed. Liver index (liver/body weight ratio), serum activities of liver-associated enzymes, blood lipids, liver index, fasting blood glucose, fasting plasma insulin, liver histology and liver ultrastructure were assayed in all the groups ......
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