银杏叶提取物抗大鼠肝纤维化中激活素A和肝细胞凋亡的作用
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时昭红, 刘 浩, 刘 嵩, 张介眉, 涂晋文
银杏叶提取物;肝纤维化;激活素A;肝细胞凋亡;免疫组化;逆转录-聚合酶链反应,时昭红,刘浩,刘嵩,张介眉,涂晋文,时昭红,通讯作者,Roleso
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时昭红, 刘浩, 刘嵩, 张介眉, 武汉市第一医院消化内科 湖北省武汉市 430022
涂晋文, 湖北省中医学院 湖北省武汉市 430061
时昭红, 2006年湖北中医学院博士研究生毕业, 副主任医师, 主要从事肝纤维化防治方面的研究.
湖北省卫生厅科研计划资助项目, No. 2004079025
通讯作者: 时昭红, 430022, 湖北省武汉市, 武汉市第一医院消化内科. liuhao678@163.com
收稿日期: 2006-05-10 接受日期: 2006-05-22
Roles of activin A and hepatocellular apoptosis in the anti-liver fibrosis process induced by Ginkgo biloba extract in rats
Zhao-Hong Shi, Hao Liu, Song Liu, Jie-Mei Zhang, Jin-Wen Tu
Zhao-Hong Shi, Hao Liu, Song Liu, Jie-Mei Zhang, Department of Gastroenterology, Wuhan First Municipal Hospital, Wuhan 430022, Hubei Province, China
Jin-Wen Tu, Hubei College of Traditional Chinese Medicine, Wuhan 430061, Hubei Province, China
Supported by the Science Foundation from Health department of Hubei Province, No. 2004079025
Correspondence to: Zhao-Hong Shi, Department of Gastroenterology, Wuhan First Municipal Hospital, Wuhan 430022, Hubei Province, China. liuhao678@163.com
Received: 2006-05-10 Accepted: 2006-05-22
Abstract
AIM: To investigate the effects of Ginkgo biloba extract (GBE) on CCl4-induced liver fibrosis as well as the underlying mechanisms.
METHODS: Thirty adult male Sprague Dawley rats were randomized into 3 groups: control group (n = 10), model group (n = 10) and treatment group (n = 10). Except the rats in the control group, the others were intraperitoneally injected with 500 mL/L CCl4 (1 mL/kg) to induce liver cirrhosis (twice a week, for 8 weeks). Moreover, the rats in treatment group were intragastrically administered with GBE (0.4 g/kg) for 8 weeks. At the end of the 8th week, all the rats were sacrificed. Blood samples were collected for the determination of biochemical indicators. Tissue samples were used for histopathological examinations. The expression of activin A was determined by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) ......
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