胃癌和癌前病变中错配修复基因hMLH1的表达及意义
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肖桂珍, 刘希双
错配修复基因;hMLH1;胃肿瘤;腺瘤性息肉;胃炎;免疫组化,肖桂珍,刘希双,肖桂珍,通讯作者,ExpressionofDNAmismatchrep
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肖桂珍, 刘希双, 青岛大学医学院附属医院内镜诊治中心 山东省青岛市 266003
肖桂珍, 1989年毕业于菏泽医学专科学校, 2004级青岛大学医学院在读研究生.
通讯作者: 刘希双, 266003, 山东省青岛市江苏路16号, 青岛大学医学院附属医院内镜诊治中心. liuxishuang1@sina.com
电话: 0532-82911525
收稿日期: 2006-05-15 接受日期: 2006-06-27
Expression of DNA mismatch repair gene hMLH1 and its significance in gastric cancer and premalignant lesions
Gui-Zhen Xiao, Xi-Shuang Liu
Gui-Zhen Xiao, Xi-Shuang Liu, Center of Endoscope, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China
Correspondence to:Dr. Xi-Shuang Liu, Center of Endoscope, the Affiliated Hospital of Qingdao University Medical College, 16 Jiangsu Road, Qingdao 266003, Shandong Province, China. liuxishuang1@sina.com
Received:2006-05-15 Accepted:2006-06-27
Abstract
AIM: To investigate the expression of DNA mismatch repair gene hMLH1 and its clinical significances in gastric cancer and premalignant lesions.
METHODS: Immunohistochemical technique was used to detect the expression of hMLH1 protein in 20 cases of chronic superficial gastritis, 20 cases of chronic atrophic gastritis complicated with intestinal metaplasia, 8 cases of adenomatous polyp, 58 cases of gastric cancer and the corresponding cancer-adjacent mucosa.
RESULTS: The hMLH1 protein was expressed mostly in epithelial cytoplasm and a little in cell nucleus. The positive rate of hMLH1 expression in chronic superficial gastritis and chronic atrophic gastritis with intestinal metaplasia were all 90%, which were significantly higher (χ2 = 9.741, P = 0.02) than those in adenomatous polyp (62.5%) and the corresponding cancer-adjacent mucosa (62.1%). The positive rate of hMLH1 expression was not significantly different between gastric cancer (72.4%) and the others (P > 0.05). Of 58 cases of cancer-adjacent mucosa, 21 (36.2%) were with chronic superficial gastritis, and 37 (63 ......
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