乳腺肿瘤；_转移；_淋巴结；_CCR7____

趋化因子受体CCR7在乳腺癌淋巴结转移中的作用

http://www.100md.com 《第四军医大学学报》 2006年第13期

乳腺肿瘤；,转移；,淋巴结；,CCR7,,乳腺肿瘤；,转移；,淋巴结；,CCR7,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Effect of chemokine receptor CCR7 in breast cancer tissue on lymph node metastasis

    ZHU Xun，ZHEN LinLin，ZHENG Wei，WANG HanJin，WANG XuanYi, WU ZhengYan

    Department of General Surgery, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China

    【Abstract】 AIM: To detect the expressions of chemokine receptor CCR7 protein and its mRNA in breast carcinoma, and to discuss their relationship with lymph node metastasis. METHODS: The expressions of chemokine receptor CCR7 mRNA and protein in 42 cases of breast carcinoma and 10 cases of breast fibroadenoma tissue were detected by reverse transcriptionpolymerase chain reaction (RTPCR) and SP immunohistochemical technique. RESULTS: There were 18 cases of positive expression of CCR7 mRNA and 15 of CCR7 protein in 42 cases of breast carcinoma tissue. The positive expression rate of CCR7 protein (11.1%) in patients without lyphm node metastasis was significantly lower than that (54.2%) in patients with lyphm node metastasis (P<0.01). The positive rate in clinical stage Ⅰ,Ⅱ and Ⅲ were 0%, 39.1%, 60.0%, respectively (P<0.01). The positive expression of CCR7 was correlated with lymph node metastasis as well as clinical stage. CONCLUSION: CCR7 may contribute to lyphm node metastasis in breast cancer. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/08/07/13/12/81.htm

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