Effects of Chinese medicine Jiangtangª²yisheng Capsule on animal models of experimental diabetes

    MA Yuª²Peng£¬ ZHANG Zhongª²Xin£¬ ZHANG Yanª²Ying£¬ LI Jiª²Xia£¬ LI Guangª²Yuan

    Department of Integrated Traditional Chinese and Western Medicine, Zhangye Hospital of Traditional Chinese Medicine, Zhangye 734000, China, Department of Pharmacology, Gansu College of Traditional Chinese Medicine, Lanzhou 730000 , China

    ¡¾Abstract¡¿ AIM: To probe into the pharmacological influence of Chinese medicine Jiangtangyisheng Capsule (ginseng, rehmannia dride rhizome, radix astragali, coptis chinensis, leech) on diabetes. METHODS: The changes of blood sugar, sugar tolerance, insulin release, glucagon release, hepatic glucogen in experimental diabetic rats were monitored after the treatment of Jiangtangyisheng Capsule. RESULTS: The capsule had an obvious effect of bringing down the blood sugar of the rat models with experimental diabetes caused by streptomycin (P<0.01), could improve the endurance of the blood sugar (P<0.01) and increase the amount of insulin in blood serum (P<0.01), meanwhile, brought down the amount of high blood sugar in plasma (P<0.01), and adjusted the steps of some blood sugar metaª²bolism of the rats with experimental diabetes, for example, promoting the synthesis of liver glycogen and muscle glycogen. It could also bring down the raise of mouse blood sugar that was caused by adrenalin(P<0.01). CONCLUSION: The capsule has the effects of bringing down blood sugar, improving the endurance of blood sugar, promoting insulin release and the synthesis of liver glycogen and muscle glycogen, and also can decrease the amounts of glucagon in plasma. ......