【摘要】目的 探讨恶性间皮瘤的临床病理特征及诊断与鉴别诊断要点。方法 观察分析1例纵隔恶性间皮瘤临床病理特点,结合文献探讨其临床表现、病理形态特点及鉴别诊断。结果 恶性间皮瘤呈双向分化，在梭形细胞间质中有片状、灶状或巢状上皮细胞团，免疫组化染色显示瘤细胞CK (+) 、 Vimenin (+) 、 Desmin (+) 、 NSE(+) 、 CD99 (+)、CEA (+) 、 MYOD1 (+)。结论 纵隔恶性间皮瘤预后差，临床易误诊，其组织形态复杂，应与纵隔转移癌、恶性神经鞘瘤等鉴别。

    【关键词】纵隔； 临床病理； 免疫组化

    Malignant mesothelioma of the mediastinum : a case report and review of literature

    MA Fen-xian，LV Guo-qing.

    Department of Pathology,Changji People’s Hospital,Xinjiang 831100，China

    【Abstract】 Objective To study clinicopathologic features and to analyze differential of malignant mesothelioma.Methods A case of malignant mesothelioma of the mediastinum was observed with pathologic examination and the literaturenas briefly reviewed.Results The malignant mesothelioma showed biphasic forms, fibrous component and neoplastic cells arranged in stream-or nest-or cabinet-like forms, immumohistochemical staining showed that the neoplastic cells were positive for Vimentin, Desmin, NSE, CD99, CEA, MYOD1.Conclusion Malignant mesothelioma of mediastinum is a relatively rare poor prognosis,with the combination of clinical histopathological and immunohistochemical data, its correct diagnosis and differential diagnosis can be made. ......