克林霉素诱导实验在阳性球菌药敏实验中的应用
革兰阳性球菌；红霉素；克林霉素；D实验,,革兰阳性球菌；红霉素；克林霉素；D实验,1材料,2方法,3结果,4讨论,【参考文献】
【摘要】目的 探讨阳性球菌中红霉素诱导克林霉素耐药性的发生情况，合理指导临床用药。方法 MIC法检测某院579株阳性球菌对克林霉素和红霉素的耐药情况;双纸片法检测可诱导克林霉素耐药。结果 金黄色葡萄球菌、凝固酶阴性球菌及β溶血链球菌对红霉素和克林霉素同时耐药率分别占76.5%、50.8%、48.0%。在红霉素耐药而克林霉素敏感的菌株中，D实验阳性分别占65.0%、41.0%、34.0%。在红霉素敏感株中未见克林霉素诱导性耐药。结论 临床微生物实验室应加强可诱导克林霉素耐药性的检测，指导临床有效合理的使用抗生素。【关键词】革兰阳性球菌；红霉素；克林霉素；D实验
The amplication of clisdamycin induction test in clinical microbiology susceptiability laboratories
LIN Li-zhong,WANG Xiao-fei,YANG Cui-yun,et al.The First Peoples Hospital of Changde City,Hunan 415003,China
【Abstract】 Objective To investigate the resistance of erthromycin and clidamycin in Gram-positive coccus and help to reasonably use clindamycin. Methods Use of MIC to detect 578 isolates randomly collected from January to September in our hospital, double antimicrobial agents detect the clidamycin induce test.Results Co-resistance to erythromycin and clindamycin accounted for 76.5%,50.8%,48.0% in Staphylococcus aureus,coagulase-negative coccus and beta-hemolylic streptococcus.Among the 129 eryRcliS isolates,the rate of inducible resistance to clindamycin (D-test positive) was 65.0%,41.0%,34.0% respectivelly.For all the eryScliS isolates,clisdamycin induce test are negative.Conclusion The detection of inducible clindamycin resistance must be stressed in clinical microbiology laboratory to provide good support for rational antibiotic therapy. ......
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