大肠癌和大肠腺瘤COX-2和BFGF表达的意义
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林瑶光, 韦良宏
大肠癌;COX-2;BFGF,林瑶光,韦良宏,林瑶光,通讯作者:,电话:,收稿日期:,接受日期:,Expressionandsignifi
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林瑶光, 韦良宏, 广西医科大学第一附属医院老年消化内科 广西壮族自治区南宁市 530021
林瑶光, 教授, 硕士生导师, 从事消化系统肿瘤的早期诊断与治疗.广西科技厅科研基金资助课题(桂科基), No. 0342010-4
通讯作者: 林瑶光, 530021, 广西壮族自治区南宁市, 广西医科大学第一附属医院老年消化内科. lyg57@163.com
电话: 0771-5356596
收稿日期: 2006-05-20 接受日期: 2006-06-05
Expression and significance of cyclooxygenase-2 and basic fibroblast growth factor in colorectal carcinoma and adenoma
Yao-Guang Lin, Liang-Hong Wei
Yao-Guang Lin, Liang-Hong Wei, Department of Gerontism Gastroenterology, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Supported by the Science and Technology Government Agency Research Program of Guangxi Zhuang Autonomous Region, China, No. 0342010-4
Correspondence to: Yao-Guang Lin, Department of Gerontism Gastroenterology, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. lyg57@163.com
Received: 2006-05-20 Accepted: 2006-06-05
Abstract
AIM: AIM: To investigate the mechanism of cyclooxygenase-2 (COX-2), basic fibroblast growth factor (BFGF) in the carcinogenesis of colorectal carcinoma and adenoma.
METHODS: Intestinal biopsy specimens were collected from patients with colorectal carcinoma (n = 49), adenoma (n = 25), and normal mucosa (n = 20), and the expression of COX-2 and BFGF were detected by immunohistochemical staining (SP method).
RESULTS: The positive rates of COX-2, BFGF expression were 59.2%, 69.3% in colorectal carcinoma, and 52.0%, 56.0% in adenoma, respectively. COX-2 and BFGF expression were not detected in normal intestinal mucosa. The positive rates of COX-2 and BFGF expression were not significantly difference between colorectal carcinoma and adenoma (P > 0.05). The expression of COX-2 and BFGF were not significantly correlated with the gender, age, tumor size, tumor location, and cell differentiation, but had marked correlations with Dukes stages (stage C, D vs A, B: 81 ......
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