肠癌组织P57^kip2和Ki67表达对侵袭性的影响

http://www.100md.com 狄建忠, 赵中辛, 郑 起, 樊友本, 汪 昱

P57kip2;Ki67;结肠癌;免疫组化狄建忠,赵中辛,郑起,樊友本,汪昱.结肠癌组织P57kip2和Ki67表达对侵袭性的影响. 世界华人消化杂志2006;14(22)2203-220

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     狄建忠, 郑起, 樊友本, 汪昱, 上海交通大学附属第六人民医院普外科 上海市 200233

    赵中辛, 同济大学医学院附属上海市东方医院普外科 上海市 200120狄建忠, 在读硕士, 主治医师, 主要从事胃肠道肿瘤的研究.

    通讯作者: 郑起, 200233, 上海市, 上海交通大学附属第六人民医院普外科. zhengqi1957@yahoo.com.cn

    收稿日期: 2006-06-02 接受日期: 2006-06-14

    Expression of P57^kip2 and Ki67 in colon adenocarcinoma

    Jian-Zhong Di, Zhong-Xin Zhao, Qi Zheng, You-Ben Fan, Yu Wang

    Jian-Zhong Di, Qi Zheng, You-Ben Fan, Yu Wang, Department of General Surgery, the Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai 200233, China

    Zhong-Xin Zhao, Department of General Surger, the Affiliated Dongfang Hospital of Tongji University Medical College, Shanghai 200120, China

    Correspondence to: Qi Zheng, Department of General Surgery, the Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai 200233, China. zhengqi1957@yahoo.com.cn

    Received: 2006-06-02 Accepted: 2006-06-14

    Abstract

    AIM: To investigate the expression of P57^kip2 and Ki67 and their roles in the carcinogenesis and progression of colon adenocarcinoma.

    METHODS: Avidin-biotin-peroxidase complex (ABC) immunohistochemistry was used to detect the expression of P57^kip2 and Ki67 in normal colon tissues (n = 10), colon benign tumor (n = 10), and colon adenocarcinoma (n = 69).

    

    RESULTS: The expression of P57^kip2 and Ki67 were not significantly different between normal colon tissues and colon benign tumor (P > 0.05). The expression of P57^{kip2 in colon cancer was significantly lower than that in normal colon tissues and colon benign tumor (P = 0 ......}

    http://www.100md.com/html/DirDu/2006/08/08/18/02/50.htm

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