银杏苦内酯B对重症急性胰腺炎大鼠血浆细胞因子的影响
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邸 瑶, 夏时海, 佟长青
胰腺炎;细胞因子;银杏苦内酯B邸瑶,夏时海,佟长青,银杏苦内酯B对重症急性胰腺炎大鼠血浆细胞因子的影响. 世界华人消化杂志2006;14(22)2169-2173,银杏苦内酯B对重症急性胰
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邸瑶, 佟长青, 武警医学院生理教研室 天津市 300162
夏时海, 武警医学院附属医院消化内科胰腺中心 天津市300162邸瑶, 2003年河北医科大学硕士生, 助教, 主要从事人体生理学研究和教学.国家自然科学基金资助项目, No. 30300465
武警医学院科研基金, No. WY2002-19
通讯作者: 夏时海, 300162, 天津市河东区成林路, 武警医学院附属医院消化内科胰腺中心. xshhcx@sina.com
电话: 022-60578765 传真: 022-24370605
收稿日期: 2006-04-24 接受日期: 2006-05-11
Effect of Ginkgolide B on plasma levels of cytokines in severe acute pancreatitis in rats
Yao Di, Shi-Hai Xia, Chang-Qing Tong
Yao Di, Chang-Qing Tong, Department of Physiology, Medical College of Chinese People's Armed Police Force, Tianjin 300162, China
Shi-Hai Xia, Center of Pancreas, Department of Gastroenterology, the Affiliated Hospital of Chinese People's Armed Police Force Medical College, Tianjin 300162, China
Supported byNational Natural Science Foundation of China, No. 30300465, and Scientific Research Foun from Medical College of Chinese People's Armed Police Force, No. WY2002-19
Correspondence to: Dr. Shi-Hai Xia, Center of Pancreas, Department of Gastroenterology, the Affiliated Hospital of Chinese People's Armed Police Force Medical College, Chenglin Road, Hedong District, Tianjin 300162, China. xshhcx@sina.com
Received: 2006-04-24 Accepted: 2006-05-11
AbstractAIM:To observe the level changes of tumor necrosis factor-alpha (TNF-a), platelet activating factor (PAF), interleukin-10 (IL-10), interleukin-12 (IL-12) and soluble TNF receptors (sTNFR) in rats with severe acute pancreatitis (SAP) and the influences of Ginkgolide B (BN52021) on the changes.
METHODS: Male Wistar rats were randomly divided into 3 groups: SAP model group (SAP,n = 15), BN52021 treatment group (BN, n = 15) and negative control group (NC, n = 15). SAP was induced by retrograde infusion of 50 g/L sodium taurocholate into the pancreatic duct of rats. Sham operation was performed in the rats of NC group, while the rats in SAP and NC groups received the femoral vein injection of normal saline (5 mL/kg) 15 min after induction of SAP ......
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