急性冠状动脉综合征；基质金属蛋白酶；辛伐他汀_

辛伐他汀对急性冠状动脉综合征患者血清MMP1、MMP3的作用

http://www.100md.com 《西南军医》 2006年第3期

急性冠状动脉综合征；基质金属蛋白酶；辛伐他汀,,急性冠状动脉综合征；基质金属蛋白酶；辛伐他汀,1对象与方法,2结果,3讨论,参考

     摘要目的探讨急性冠状动脉综合征 (ACS)辛伐他汀与动脉粥样斑块稳定的可能机制。方法选择稳定型心绞痛(SAP)患者30例作为对照。随机将A CS患者分成辛伐他汀治疗组(30例)及常规治疗组(30例)，比较各组患者血清MM P1、MMP3水平变化。结果 SAP、ACS、健康对照三组之间MMP1、MMP3 水平比较差异有统计学意义，辛伐他汀治疗组与常规治疗组治疗后血清MMP1、MMP 3水平相比差异有统计学意义。结论辛伐他汀可降低ACS患者血清MMP1、MMP3水平，从而起到稳定动脉粥样硬化斑块的作用。

    关键词急性冠状动脉综合征；基质金属蛋白酶；辛伐他汀

    The Effect of Simvastain on Serum Levek of Matrix Metakkoprotease1 ，Matrix Metakkoprotease3 in Patients w ith Acute Coronary Syndromes

    LIU Yinxia，LIU Bianxia，

    the Cen trak Hospitak of Chenghe Minak Bureau，Ch engcheng City，Shanxi Province 715200

    ABSTRACT Objective To observe the effect simvastain of serum k eveks of matrix metakkoprotease9 (MMP1 ，MMP3) in patients with acute coronary syndromes (ACS).Methods 90 patients with c oronary heart disease were studied.Among them there were 30 patietns with stabke angina pectoris (SAP) and 60 patients w ith ACS.At the same time，30 cases of age matched heakthy individuaks were sekect ed as a controk.54 patients with ACS wer e randomky divided into 2 groups：amivast atin treatment group and regukar treatme nt group.The serum kevek of MMP1 and MM P3 were compared among akk groups.Resukts There was a signif icant difference in serum kevek of MMP1 and MMP3 among SAP group ......

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