幽门螺杆菌疫苗接种小鼠产生免疫后胃炎的影响因素
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陈 洁, 陈旻湖, 王锦辉, 朱森林
幽门螺杆菌;疫苗;免疫后胃炎;小鼠,陈洁,陈旻湖,王锦辉,朱森林,陈洁,通讯作者,Influencefactorsofpost-immunization
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陈洁, 陈旻湖, 王锦辉, 朱森林, 中山大学附属第一医院消化内科 广东省广州市 510080
陈洁, 2002年获中山大学医学博士, 讲师, 2002-2004年德国马格德堡Otto-von-Guericke大学医学院胃肠、肝病及感染病系消化肿瘤实验室博士后, 主要从事幽门螺杆菌相关疾病以及消化道肿瘤研究.
广东省自然科学基金资助项目, No. 021889
通讯作者: 陈旻湖, 510080, 广东省广州市中山二路58号, 中山大学附属第一医院消化内科. chenminhu@vip.163.com
电话: 020-87332916 传真: 020-87332916
收稿日期: 2006-06-15 接受日期: 2006-06-27
Influence factors of post-immunization gastritis after Helicobacter pylori vaccine immunization in mice
Jie Chen, Min-Hu Chen, Jin-Hu Wang, Sen-Lin Zhu
Jie Chen, Min-Hu Chen, Jin-Hu Wang, Sen-Lin Zhu,Department of Gastroenterology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Supported bythe Natural Science Foundation of Guangdong Province, No. 021889
Correspondence to:Dr. Min-Hu Chen, Department of Gastroenterology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China. chenminhu@vip.163.com
Received:2006-06-15 Accepted:2006-06-27
Abstract
AIM: To explore the influence factors of post-immunization gastritis after H pylori vaccine immunization in mice.
METHODS: (1) C57BL/6 and BALB/c mice were orally immunized with H pylori vaccine (H pylori whole cell sonicate antigen plus mucosa adjuvant cholera toxin). Gastric H pylori infection and inflammation were evaluated after H pylori challenge. (2) C57BL/6 mice were orally immunized with H pylori vaccine, and then challenged by different amounts of H pylori. Gastric H pylori infection and inflammation were evaluated after H pylori challenge. (3) C57BL/6 mice were immunized orally or intraperitoneally with H pylori vaccine. Gastric H pylori infection and inflammation were evaluated afterH pylori challenge at different time points. (4) Infected C57BL/6 mice were orally immunized with H pylori vaccine, and gastric H pylori infection and inflammation were evaluated after immunization at different time points ......
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