国产奎硫平联合碳酸锂治疗急性躁狂发作对照研究
躁狂发作；奎硫平；氯氮平；碳酸锂,,躁狂发作；奎硫平；氯氮平；碳酸锂,【摘要】,【关键词】,1对象与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨奎硫平联合碳酸锂治疗急性躁狂发作的疗效及安全性。 方法 将69例急性躁狂发作患者随机分为两组，研究组34例，对照组35例，两组均在应用碳酸锂治疗的基础上分别联合奎硫平和氯氮平治疗，疗程6w；采用躁狂量表及副作用量表评定临床疗效和不良反应。 结果 治疗第6w末，研究组总有效率为94.1%、对照组为94.2%，两组总体疗效相当；研究组起效时间稍迟于对照组(P<0.05)，不良反应明显少于对照组(P<0.05)。结论 奎硫平联合碳酸锂治疗急性躁狂发作疗效肯定、安全性高、依从性好，是治疗急性躁狂发作较好的选择方案。【关键词】 躁狂发作；奎硫平；氯氮平；碳酸锂
A control study of domestic quetiapine combined with lithium in the treatment of acute manic episode
Li Aifeng,Yang Qiong, Deng Lianghua, et al
(Guangzhou Mental Hospital, 510370, Guangdong, China)
【Abstract】 Objective To explore curative effects and safety of quetiapine combined with lithium in acute manic episode. Methods Sixtynine patients with acute mania(CCMD3) were randomly assigned to two groups: research group(n=34) receiving quetiapine plus lithium and control group(n=35) clozapine plus lithium for 6 weeks. Curative effectiveness were assessed with BechRafaelsen Mania Rating Scale(BRMS) and side effects with the Treatment Emergent Symptom Scale(TESS).Results After 6 week treatment, total effective rates of the 2 groups were 94.1% and 94.2% respectively and gross curative effects equivalent; compared with control group, research group took effect slightly later(P<0.05) and side effects were significantly fewer(P<0.05).Conclusion Quetiapine plus lithium has better curative effect, higher safety and well compliance and is a better selection in the treatment of acute mania. ......
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