转化生长因子β1和结缔组织生长因子在肝纤维化中的表达
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丁 宁, 李 岩
转化生长因子β1;结缔组织生长因子;肝纤维化,转化生长因子β1和结缔组织生长因子在肝纤维化中的表达,丁宁,李岩,通讯作者,Expressionoftransforminggrowthfactor-β1
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丁宁, 李岩, 中国医科大学附属二院消化内科 辽宁省沈阳市 110001
通讯作者: 李岩, 110004, 辽宁省沈阳市, 中国医科大学附属二院消化内科. yanli0227@126.com
电话: 024-83955189 传真: 024-31290392
收稿日期: 2006-05-20 接受日期: 2006-06-30
Expression of transforming growth factor-β1 and connective tissue growth factor in hepatic fibrosis
Ning Ding, Yan Li
Ning Ding, Yan Li,Department of Gastroenterology, the Second Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Correspondence to:Yan Li, Department of Gastroenterology, the Second Affiliated Hospital of China Medical University, Shenyang 110004, Liaoning Province, China. yanli0227@126.com
Received:2006-05-20 Accepted:2006-06-30
Abstract
AIM: To detect the expression of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) as well as their correlations in the different stages of hepatic fibrosis.
METHODS: Liver puncture was performed on 41 patients with chronic viral hepatitis. The expression of TGF-β1 and CTGF were detected by immunohistochemistry and other serum fibrosis markers were examined by enzyme-linked immunosorbent assay (ELISA). Subsequently, the images of TGF-β1 and CTGF were analyzed for semi-quantification by multimedia color image analyzer.
RESULTS: The expression of TGF-β1 and CTGF were increased with the elevation of fibrosis stage (F = 49.56, 23.01, both P < 0.05) except S1 and S2 stage. TGF-β1 expression was not significantly different among patients of G1, G2, G3 and G4 stage. CTGF expression of G4 stage was distinctly different from that of G1, G2 and G3 stage, while no difference was observed among patients of G1, G2 and G3 stage. There was closely positive correlation between the levels of TGF-β1 and CTGF in hepatic tissue (r = 0 ......
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