单甲氧基聚乙二醇对大鼠胰岛的免疫修饰作用
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赵 刚, 崔 静, 黎少山, 殷 涛, 胡伟国,
胰岛;单甲氧基聚乙二醇;免疫修饰,赵刚,崔静,黎少山,殷涛,胡伟国,吴河水,王春友,赵刚,通讯作者,Immunemodificationofratisletb
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赵刚, 崔静, 黎少山, 殷涛, 胡伟国, 吴河水, 王春友, 华中科技大学同济医学院附属协和医院胰腺外科中心 湖北省武汉市 430022
赵刚, 博士, 讲师, 毕业于华中科技大学同济医学院, 现工作于附属协和医院胰腺外科中心, 主要从事胰腺疾病基础与临床研究.
湖北省卫生厅青年科技人才资助项目, No. QJX2005-4
通讯作者: 王春友, 430022, 湖北省武汉市, 华中科技大学同济医学院附属协和医院胰腺外科中心. chunyouwang52@126.com
收稿日期: 2006-05-08 接受日期: 2006-07-19
Immune modification of rat islet by methoxy-polyethylene glycol
Gang Zhao, Jing Cui, Shao-Shan Li, Tao Yin, Wei-Guo Hu, He-Shui Wu, Chun-You Wang
Gang Zhao, Jing Cui, Shao-Shan Li, Tao Yin, Wei-Guo Hu, He-Shui Wu, Chun-You Wang,Pancreatic Surgery Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Supported byYoung Scholar Foundation of Health Department of Hubei Province, No. QJX2005-4
Correspondence to:Chun-You Wang, Pancreatic Surgery Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. chunyouwang52@126.com
Received: 2006-05-08 Accepted:2006-07-19
Abstract
AIM: To investigate the insulin secretion changes of rat islets after immune modification of methoxy-polyethylene glycol (mPEG).
METHODS: The islets isolated from Wistar rats were divided into control group and mPEG-treated groups (with 200, 300 and 400 g/L mPEG, respectively). After culture for 24 h, the viability of islets was detected by dithizone staining, and insulin secretion function was examined by glucose stimulation test. The islets from different groups were mixed with splenic lymphocyte from SD rats to evaluate the immunogenicity.
RESULTS: The viability of islets or the insulin secretion function in the three treatment groups was not significantly different from that in the control group ......
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