CGRP在大鼠胃痛觉过敏形成机制中的作用
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章菲菲, 莫剑忠, 吕有灵, 陈胜良, 吕 鸣,
功能性消化不良;内脏传入神经;降钙素基因相关肽,章菲菲,吕有灵,吕鸣,张珏莹,杨龙,莫剑忠,陈胜良,章菲菲,通讯作者,Roleofcalcitoningene
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章菲菲, 吕有灵, 吕鸣, 张珏莹, 杨龙, 武警上海总队医院消化科 上海市 201103
莫剑忠, 陈胜良, 上海交通大学附属仁济医院消化科 上海消化疾病研究所 上海市 200001
章菲菲, 2005年上海交通大学医学院博士, 主治医师, 主要从事功能性消化系统疾病的研究.
通讯作者: 莫剑忠, 200001, 上海市山东中路145号, 上海交通大学附属仁济医院消化科. jianzhong_mo@hotmail.com
收稿日期: 2006-06-08 接受日期: 2006-07-10
Role of calcitonin gene-related peptide in gastric hypersensitivity in rats
Fei-Fei Zhang, Jian-Zhong Mo, You-Ling Lv, Sheng-Liang Chen, Ming Lv, Jue-Ying Zhang, Long Yang
Fei-Fei Zhang, You-Ling Lv, Ming Lv, Jue-Ying Zhang, Long Yang,Department of Gastroenterology, Shanghai General Hospital of Armed Police, Shanghai 201103, China
Jian-Zhong Mo, Sheng-Liang Chen,Shanghai Institute of Digestive Disease; Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University, Shanghai 200001, China
Correspondence to: Jian-Zhong Mo,Shanghai Institute of Digestive Disease; Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University, Shanghai 200001, China. jianzhong_mo@hotmail.com
Received: 2006-06-08 Accepted:2006-07-10
Abstract
AIM: To explore the role of calcitonin gene-related peptide (CGRP) in gastric distention-induced visceral pain in conscious rats.
METHODS: Balloons were implanted into the stomach of 24 male Sprague Dawley rats. In this study we observed the following outcomes: (1) effects of noxious distention or CGRP intravenous injection on gastric sensitivity; (2) effects of a specific CGRP receptor antagonist, hCGRP8-37 on gastric hypersensitivity; (3) relationship between the doses of CGRP & hCGRP8-37 and their effects on gastric sensitivity. Gastric sensitivity was evaluated with gastric pain threshold determined by electromyography (EMG) of the neck muscles.
RESULTS: After intravenous injection of CGRP, the values of gastric pain threshold were 11.7 ± 2.6, 19.2 ± 2.0, and 18.3 ± 2.5 mmHg in experiment group, operation control group, and normal saline group, respectively, and there was significant difference between the former one and latter two (P < 0 ......
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