表面增强的激光解析电离飞行时间质谱技术在肝细胞癌血清学诊断中的应用
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田字彬, 刘 华, 孙桂荣, 孔心涓, 张翠萍,
肝细胞癌;蛋白质组学;肿瘤标志物;表面增强的激光解析电离飞行时间质谱,田字彬,孔心涓,张翠萍,刘华,孙桂荣,王斌,田字彬,通讯作者
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田字彬, 孔心涓, 张翠萍, 青岛大学医学院附属医院消化内科 山东省青岛市 266003
刘华, 青岛大学医学院附属医院内镜中心 山东省青岛市 266003
孙桂荣, 青岛大学医学院附属医院临床免疫检验中心 山东省青岛市 266003
王斌, 青岛大学医学院微生物教研室 山东省青岛市 266021
田字彬, 1995年上海第二医科大学博士, 1989-2003日本福井医科大学访问学者, 主任医师, 教授, 从事消化系疾病的诊治研究.
青岛市科技局资助项目, No. 2004-11
通讯作者: 田字彬, 266003, 山东省青岛市江苏路16号, 青岛大学医学院附属医院消化内科. tianzb@qdumh.qd.sd.cn
电话: 0532-82911304 传真: 0532-82911999
收稿日期: 2006-06-21 接受日期: 2006-07-10
Application of surface enhanced laser desorption ionization time-of-flight mass spectrometry technology in the diagnosis of hepatocellular carcinoma
Zi-Bin Tian, Hua Liu, Gui-Rong Sun, Xin-Juan Kong, Cui-Ping Zhang, Bin Wang
Zi-Bin Tian, Xin-Juan Kong, Cui-Ping Zhang,Department of Gastroenterology, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China
Hua Liu,Department of Endoscopy, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China
Gui-Rong Sun,Clinical Immunologic Center, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China
Bin Wang,Department of Microbiology, Qingdao University Medical College, Qingdao 266021, Shandong Province, China
Supported by Qingdao Technology Agency, No. 2004-11
Correspondence to:Dr. Zi-Bin Tian, Department of Gastroenterology, the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, Qingdao 266003, Shandong Province, China. tianzb@qdumh.qd.sd.cn
Received: 2006-06-21 Accepted:2006-07-10
Abstract
AIM: To explore tumor markers for the diagnosis of hepatocellular carcinoma (HCC) through detecting the serum protein spectrum differently expressed between hepatitis B virus (HBV) carriers and HCC patients.
METHODS: We detected the serum protein spectrum in 27 HCC patients, 27 HBV carriers and 25 healthy controls using surface enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technique, and the diagnosis model was established through analyzing the detected data by biomarker patterns software (BPS) 5 ......
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