肝细胞核因子4α和3β在人主要器官中的表达
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龙 云, 唐 红, 刘 聪, 何 芳, 刘 丽,
肝细胞核因子4α;肝细胞核因子3b;器官;表达;HBV复制,龙云,唐红,刘聪,何芳,刘丽,赵连三,黄飞骏,龙云,通讯作者,Expressionofhepat
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龙云, 唐红, 刘聪, 何芳, 刘丽, 赵连三, 四川大学华西医院感染性疾病中心 四川大学生物治疗国家重点实验室感染性疾病研究室 610041
黄飞骏, 四川大学华西基础医学与法医学院 四川省成都市 610041
龙云, 医学硕士, 主要从事病毒性肝炎的研究工作.
国家杰出青年科学基金资助项目, No. 30325036
通讯作者: 黄飞骏, 610041, 四川省成都市, 四川大学华西基础医学与法医学院. fjhuang600123@163.com
电话: 028-81822623
收稿日期: 2006-06-21 接受日期: 2006-07-31
Expression of hepatocyte nuclear factor 4α and 3β in human tissues
Yun Long, Hong Tang, Cong Liu, Fang He, Li Liu, Lian-San Zhao, Fei-Jun Huang
Yun Long, Hong Tang, Cong Liu, Fang He, Li Liu, Lian-San Zhao,Center of Infectious Diseases, West China Hospital; Department of Infectious Diseases, National Key Laboratory of Biological Therapy, Sichuan University, Chengdu 610041, Sichuan Province, China
Fei-Jun Huang,School of Preclinical Medicine and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China
Supported bythe Science Fund for Prominent Youths of China, No. 30325036
Correspondence to:Fei-Jun Huang, School of Preclinical Medicine and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China. fjhuang600123@163.com
Received:2006-06-21 Accepted:2006-07-31
Abstract
AIM: To investigate the expression patterns of hepatocyte nuclear factor 4α (HNF-4α) and HNF-3b in normal human tissues, so as to provide the bases for further exploration of their relationships with hepatitis B virus (HBV) replication in hepatitis B patients.
METHODS: Immunohistochemistry was used to detect the expression of HNF-4α and HNF-3b in human tissues of liver, brain, lung, kidney, heart, spleen, intestine, pancreas, stomach and thyroid from 14 corpses. The differences of their expression in different tissues were analyzed.
RESULTS: The expression patterns of HNF-4α and HNF-3b was different among the 10 kinds of human tissues (HNF-4α: F = 22.479, P < 0.01; HNF-3b: F = 13.021, P < 0 ......
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