[摘要] 目的 回顾性研究在肝功能异常患者中肝肾微粒体抗体和可溶性肝抗原/肝胰抗体检测的意义和免疫特征。方法 收集肝功能异常患者丙氨酸氨基转移酶(ALT)>40 u/L的患者血浆5500例，分别检测肝肾微粒体抗体、可溶性肝抗原/肝胰抗体和相关自身抗体，查阅临床资料。结果 5500例血浆中检测出SLA/LP阳性8例，占1.45‰，LKM阳性者4例，占0.73‰。12例阳性病例中，有乙型和丙型病毒性肝炎现症感染证据的分别有1例和2例。大多数患者同时还伴有ANA、AMA、SMA和(或)LSP等抗体阳性。结论 抗LKM-1和抗SLA/LP在我国肝病患者中出现的比例较低，抗LKM-1和抗SLA/LP是自身免疫性肝病的特征性抗体，检测此抗体对自身免疫性肝炎诊断具有重要的意义。

    [关键词] LKM-1;SLA/LP;肝炎;自身免疫性

    Study on LKM-1 and SLA/LP in Chinese patients with liver diseases

    FENG Xia,YAN Hui-ping,LIU Yan-min,et al.

    Beijing Youan Hospital,Capital University of Medical Sciences,Beijing 100069,China

    [Abstract] Objective To study the positive rates of LKM-1and SLA/LP in Chinese patients with liver diseases and analyse its characteristics.Methods 5500 sera of liver diseases with ALT >40 u/L were collected in 5 years.LKM-1,SLA/LP and related autoantibodies were tested by immumofluorescence assay and euroassay.Results Of 5500 sera only 4 cases(0.73‰)were positive for both LKM and LKM-1 antibodies.8 cases were positive for SLA/LP(1.45 ‰).Of 12 patients above,1 case had liver cirrhosis with HBsAg-positive,but HBVDNA negative;2 cases had anti-HCV positive,but HCV RNA negative.The most cases were ANA, AMA,SMA and(or)LSP positive respectively.Conclusion The prevalence of LKM-1and SLA/LP were very low in Chinese patients with liver diseases.LKM-1and SLA/LP were specific to AIH and it would be important to diagnosis of AIH. ......