【摘要】 目的 探讨硫酸基转移酶SULT1A1基因多态性与食管癌易感性的关系，及其与吸烟的交互作用。 方法 采用PCR-RFLP方法检测了163例新发食管癌患者和166例对照SULT1A1基因多态性，并应用多因素logistic回归等方法分析基因型对食管癌的危险度。 结果 ①SULT1A1Arg/Arg、Arg/His、His/His三种基因型分布在病例与对照组之间差异无显著意义(P=0.60)，病例与对照His等位基因分别为17.79%和12.57%，差异有显著性(P=0.028)，His等位基因可显著增加患食管癌的危险性(OR 调整 =1.868，95%CI为1.107～3.153);②调整混杂因素后，吸烟与SULT1A1存在交互作用(OR=2.802，95%CI为1.257～6.246);③携带有His等位基因的重度吸烟者患食管癌的危险性，是不携带His等位基因的非吸烟者的8.538倍。 结论 SULT1A1基因突变基因型是食管癌的易感基因，它与吸烟存在联合作用。

    【关键词】 多态性，限制性片段长度;食管肿瘤

    【Abstract】 Objective To study the correlation of polymorphisms of SULT1A1with the risk of esophageal cancer and smoke-gene interaction.Methods 163cases of esophageal cancer and166con-trols were collected from Heping hospital and Heji hospital of Changzhi in Shanxi Province.Blood sample were collected for detecting SULT1A1polymorphisms by PCR and RFLP.Results ①There was no significant difference in genotype of Arg/Arg，Arg/His and His/His of SULT1A1between cases and controls(P=0.60);The frequencies of His allele were17.79%and12.57%in cases and controls，re-spectively(P<0.05);the risk was significantly higher in people with His allele(OR adjusted =1.868 ......