【摘要】 目的 探讨米非司酮对早孕绒毛组织中细胞间黏附分子-1(ICAM-1)和血管细胞黏附分子-1(VCAM-1)表达的影响。 方法 采用免疫组化染色测定绒毛组织中ICAM-1和VCAM-1的表达，其中正常早孕人工流产组20例，米非司酮药物流产组22例。 结果 ICAM-1和VCAM-1在正常早孕绒毛组织中阳性表达率为80%、75%，在米非司酮药物流产组中阳性表达率为45%、41%，两者差异有显著性(P<0.05)。 结论 ICAM-1和VCAM-1与胚胎着床及维持正常早孕有关。米非司酮引起ICAM-1和VCAM-1的表达降低可能是抗早孕终止妊娠机制之一。

    【关键词】 米非司酮;绒毛;细胞间黏附分子-1;血管细胞黏附分子-1

    The effect of mifepristone on the expression of ICAM-1and VCAMA-1in chorionic villi in early pregnancy abortion women

    SONGYueqing，YAN Xiaojuan，WANG Jian，et al.

    Department of Obstetrics and Gynecology，The Third Hospital of Hebei Medical University，Shijiazhuang050051

    【Abstract】 Objective To investigate the effects of mifepristone on the expression of intercellular adhesion molecule-1(ICAM-1)and vascular cell adhesion molecule-1(VCAM-1)in chorionic villi in early pregnancy abortion women.Methods The expression of ICAM-1and VCAM-1in chorionic villi in20early pregnancy abortion women and22cases of mifepristone-induced abortion were tested by immunohistochemical technique.Results There were significant differences in the expressions of ICAM-1and VCAM-1(80% ......