【摘要】 目的 了解东阳市健康人群脑膜炎奈瑟菌(Nm)抗体水平和带菌情况，为制定预防和控制流行性脑脊髓膜炎(流脑)的有效措施提供依据。方法 采用整群抽样方法，对三种不同人群(普通人群、密切接触人群、对照组人群)采集血清标本，应用酶联免疫吸附试验检测A、C群Nm抗体；采集咽拭子，采用增菌咽拭液标本，接种于双抗血平皿37℃24h培养，分离Nm。结果 调查的444例健康人群中，A群Nm抗体阳性率78.60%，GMT为1:42.26，C群Nm抗体阳性率21.17%，GMT为1:10.36，A群Nm抗体水平较高，而C群Nm抗体水平则较低。405例接种A群流脑疫苗者抗体阳性率(81.73%)和GMT(1:44.46)明显高于39例未接种者(阳性率和GMT分别为46.15%和1:16.63)(P<0.01)，与是否接种过A群流脑疫苗有关联性。Nm带菌率为1.73%，以C群和D群为主，密切接触人群的Nm带菌率明显高于其他人群。结论 东阳市健康人群中对A群流脑具有较高的免疫力，而对C群流脑免疫力较低，一旦有传染源介入，极易引起暴发和流行，及时、有效地接种A+C流脑多糖疫苗对预防和控制流脑显得十分重要。

    【关键词】 流行性脑脊髓膜炎；脑膜炎奈瑟菌；抗体水平；带菌；监测

    An survey into the anitbody level and carrier state of Neisseria meningitidis among healthy population in Dongyang city

    WU Mei-zhong,WU Ai-lan,WEI Jun-chao.

    Dongyang Center for Disease Control and Prevention of Zhejiang Province, Dongyang 322100, China

    【Abstract】 Objective This paper aims to investigate the antibody level and carrier state of Neisseria meningitidis (Nm) among healthy population in Dongyang city,Zhejing province,So that,based on the result of this investigation, an effective measure to prevent and control epidemic cerebrospinal meningitis can be formulated. Methods Adopting cluster sampling this research collected serum samples of three population group(normal population group,closely contacted population group and control group),and enzyme-linked immunosorbent assay was used to detect Nm antibody among group A and group C.We have collected pharyngo-swabs,and inoculated those pharyngo-swab samples in dual-serum-test plates under 37℃ for 24 hours and seperated Nm. Results Among the all 444 healthy in the group A,78.60% of them tested antibody positive with the GMT being 1:42.26 while in the group C 21.17% tested antibody positive,GMT being 1:10.36. The Nm antibody level of group A was relatively high while that of group C relatively low. The rate of antibody positive and GMT among 405 people who had been inoculated A-epidemic cerebrospinal meningitis are 81.73% and 1:44.46 respectively which are remarkablely higher than those among people who had not been inoculated C rate of antibody positive and GMT being 46.15% and 1:16.63 respectively.Therefore ,we can infer that the rate and GMT are related to the inoculation of A-epidemic cerebrospinal meningitis. Conclusion Healthy people in Dongyang city are highly immune against A-epidemic cerebrospinal meningitis, but relatively lowly immune against C-epidemic cerebrospinal meningitis.Therefore, it is very likely that C-epidemic cerebrospind meningitis would occur and spread once infection source is introduced.It is extremely essential to effectively inoculate polysaccharide vaccine against A+C epidemic cerebrospinal meningitis for prevent and control it. ......