δ-榄香烯体外抗肿瘤活性研究
δ-榄香烯；MTT法；体外抗肿瘤活性,,δ-榄香烯；MTT法；体外抗肿瘤活性,1材料与方法,2方法,3结果,4讨论与结论,【参考文献】
【摘要】 目的 考察δ-榄香烯体外抗肿瘤活性。方法 采用MTT法研究δ-榄香烯对HepG2、DLD-1、H292、HeLa、HL-60、SGC-7901和MCF-7等7株肿瘤细胞株生长的抑制作用，同时考察其对正常骨髓细胞和肝细胞WRL-68生长的影响。结果 δ-榄香烯对这些肿瘤细胞的增殖抑制活性呈剂量依赖关系，即细胞增殖抑制率随着药物浓度的增加而增加，在误差允许的范围内，从δ-榄香烯对7种人肿瘤细胞株的IC50分别为：Hela 细胞为157.9μM，HL-60为154.5μM，HepG2为231.6μM，H292为233.2μM，DLD-1为222.4μM，SGC-7901为323.6μM，MCF-7为287.3μM；而在低于400μM对正常细胞增殖无显著的影响。结论 δ-榄香烯体外具有有良好的抗肿瘤活性。【关键词】 δ-榄香烯；MTT法；体外抗肿瘤活性
The study of antitumor activity in vitro of δ elemen
WANG Qian-sha,YANG Wei,LI Ming,et al.Shenyang Pharmaceutical University,Liaoning 110016,China
【Abstract】 Objective We investigated the antitumor effect of δ-elemene on several cell lines in vitro.Methods The cell prolifreration of δ-elemene were studied in HepG2, DLD-1, H292, HeLa, HL-60, SGC-7901 and MCF-7 in vitro by using MTT assay. At the same time the proliferation of bone marrow and WRL-68 were examined.Results The results showed that δ-elemene exhibited a marked antiproliferative effect on several tumor cell lines in dose- and time-dependent manners ......
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