LIU Tongª²Fang, LIU Jian, MENG Guoª²Lin, YUAN Zhi, L¦a Rong, BI Long, WANG Dengª²Hu, LIU Yanª²Wu, HU Yunª²Yu

    Chinese PLA Institute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To evaluate the feasibility of injectable calcium phosphate cement (ICPC) and fibrin sealant (FS) as an injectable compound carrier of bone morphogenic protein (BMP) . METHODS: The composites of ICPC/FS/bBMP, ICPC/FS or bBMP were injected subcutanously or implanted into thigh muscle pouches of 45 mice at random.The effect of ectopic bone formation was evaluated by biochemical examination of alkaline phosphatase (ALP) and histological examination 2 and 4 weeks after operation and the new bones were weighed in the 4th postoperative week to compare statistically the ability of bone formation of different composites. RESULTS: ICPC/FS/bBMP composite induced the formation of new bone most effectively. BBMP stimulated cess osteogenesis while ICPC/FS showed no sign of new bone formation.There was a significant difference among them (P<0.05). CONCLUSION: The injectable bone substitute, ICPC/FS/BMP, exhibited an excellent osteoinductive activity,and ICPC/FS was a good carrier for BMP. ......