食管肿瘤；癌_鳞状细胞；转化生长因子β;

食管鳞癌中TGFβ及其受体调节成分Endoglin/CD105的表达

http://www.100md.com 《第四军医大学学报》 2006年第14期

食管肿瘤；癌,鳞状细胞；转化生长因子β;,endoglin；新生血管化,病理性,,食管肿瘤；癌，鳞状细胞；转化生长因子β;,endoglin；新生血管化，病理性,食管鳞癌中TGFβ及其受体调节

     MA Jun1, GUO Min1, LI Yin2, TANG FuAi1, HU JianEn1, DUAN FangLing1

    1Institute of Digestive Diseases, Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014, 2Department of Thoracic Surgery, Tumor Hospital of Henan Province, Zhengzhou 450003, China

    【Abstract】 AIM: To investigate the expressions of TGFβ and Endoglin/CD105 in esophageal carcinoma from patients in high incidence area in north China. METHODS: The expressions of TGFβ and Endoglin/CD105 mRNA and protein were detected in 30 esophageal carcinoma samples using RNase protection assay and immunohistochemical staining. RESULTS: TGFβ1, TGFβ3 and Endoglin/CD105 mRNA, other than TGFβ2, were significantly increased in esophageal carcinoma than those of adjacent noncancerous tissue(P<0.05). There was a significant correlation between TGFβ3 and Endoglin/CD105 at mRNA level. CONCLUSION: The overexpressions of TGFβ1, TGFβ3 and Endoglin/CD105 may be involved in the regulation of angiogenesis in esophageal carcinoma. Endoglin/CD105 is an important angiogenesis marker as well as regulatory component on cell membrane in regulating the biological function of TGFβ. Endoglin/CD105 could be a potential target to antiangiogenesis therapy. ......

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