【摘要】 目的 探讨血液光量子疗法对急性白血病患者血小板输注后血小板相关抗体产生的影响。方法 将74例血小板减少的急性白血病患者随机分为两组，治疗组采用血液光量子疗法进行血小板输注，对照组单纯行血小板输注。两组均采用酶联免疫吸附法(ELISA)，在血小板输注前后定量测定血小板表面相关抗体(PAIgG和PAIgM)；计数血小板，计算1、24h血小板增值(CCI)；观察其临床效果和非溶血性输血反应(NHFTR)。结果 血小板输注前两组PAIgM及PAIgG值差异无显著性，输注后两组PAIgM差异无显著性，而治疗组PAIgG值明显低于对照组(P<0.05)；两组的CCI 1h差异无显著性，治疗组CCI 24h和临床效果明显优于对照组(P<0.05)；治疗组的NHFTR低于对照组(P<0.05)，其临床效果优于对照组(P<0.05)。结论 血液光量子疗法可减少血小板输注无效。

    【关键词】 血液光量子疗法；急性白血病；血小板输注；血小板相关抗体

    【Abstract】 Objective To investigate the effect of ultraviolet irradiation and oxygenation(UBIO)on platelet transfusion of acute leukemia patients.Methods Divide 74 platelet-reduced acute leukemia patients into two groups with randomized allocation.Therapy group transfuses platelet with UBIO,and control group only transfuses platelet.We mensurate platelet-associated antibody(PAIgG and PAIgM) of the two groups before and after platelet transfusion with Enzyme-linked Immuno Sorbent Assay (ELISA),count platelet amount and calculate 1 and 24 hour corrected count increament(CCI),and observe clinical effect and non-hemolytic febrile reaction(NHFTR).Results There is no significant difference in PAIgM and PAIgG between two groups before platelet transfusion.After transfusion,there is no significant difference in PAIgM between two groups,but PAIgG of therapy group is lower than control group (P<0.05).There is no differnece of CCI 1h between two groups.CCI 24h and clinical effect of therapy group are better than control group(P<0.05).And NHFTR of therapy group is lower than control group(P<0.05).Its clinical effect is better than control group(P<0.05).Conclusion UBIO can reduce refractoriness to platelet transfusion. ......