[摘要] 急性坏死性胰腺炎是一种始于局部而累及全身的炎症性疾病。急性坏死性胰腺炎时产生大量的胰腺炎相关性腹水，其中的弹性蛋白酶和腹膜巨噬细胞产生的多种毒性细胞因子，可经腹膜吸收入血，通过不同的分子机制导致急性坏死性胰腺炎时胰外多脏器的损害,尤其是肾、肝和肺的损害。

    [关键词] 胰腺炎相关性腹水；肾损伤；肝损伤；肺损伤

    Relation between pancreatitis-associated ascitic fluids and renal,liver and lung injury in acute necrotizing pancreatitis

    SU Yan-jun，LIU Qi-yu，ZHANG Jian-ming,et al.Department of Gastrointestinal and Thyroid Surgery,the First Affiliated Hospital of Kunming Medical College,Kunming 650032,China

    [Abstract] Acute necrotizing pancreatitis is a systemic inflammatory disease which originated in pancreas with multiple organs involved.Mass pancreatitis-associated ascitic fluids were produced in this disease,containing abundant elastase released from pancreas and toxic cytokines,produced by peritoneal macrophages can be absorbed to blood stream by peritoneum from fluids and cause multiple organs injury by different molecular mechanisms，especially renal injury,liver injury and lung injury.

    [Key words] pancreatitis-associated ascitic fluids;renal injury;liver injury;lung injury

    急性坏死性胰腺炎(acute necrotizing pancreatitis ......