[摘要] 目的 观察盐酸戊乙奎醚(长托宁)复合咪达唑仑(力月西)作为麻醉前用药，在小儿氯胺酮麻醉中对血压、心率的影响及镇静程度和麻醉苏醒期的精神反应情况。方法 40例ASA Ⅰ~Ⅱ级3~6岁患儿随机分为长托宁组和阿托品组，每组20例，均行氯胺酮静脉麻醉。记录各时点的MAP、HR、SpO2，观察患儿用长托宁或阿托品复合力月西后的镇静程度和苏醒期的精神反应情况。结果 两组病例用药后的镇静程度及麻醉苏醒期的精神反应情况比较差异无显著性(P>0.05)。HR、MAP与基础值比较，阿托品组用药后HR明显增快，MAP升高(P<0.05)；长托宁组HR、MAP基本不变。氯胺酮麻醉后，阿托品组HR显著增快，MAP显著升高(P<0.01)，长托宁组HR、MAP略有上升，但差异无显著性(P>0.05)，其中HR未超过基础值。结论 长托宁或阿托品复合力月西作为小儿氯胺酮麻醉前用药，均可产生良好的镇静作用，减少麻醉苏醒期的精神反应，但长托宁可使患儿HR、MAP保持稳定，较阿托品更适合作为小儿氯胺酮麻醉的麻醉前用药。

    [关键词] 长托宁；阿托品；力月西；氯胺酮；麻醉前用药

    Observation on penehyclidine hydrochloride combined midazolam before children underwent narcotic ketamine anesthesizing

    BAI Jin-jun,WAN Cai-hong.Department of Anesthesiology,Pinggu Hospital,Beijing 101200,China

    [Abstract] Objective To observe effects of penehyclidine hydrochloride combined midazolam before children underwent narcotic ketamine anesthesizing.Methods Forty children,aged 3~6 years,ASA Ⅰ~Ⅱ,were randomized into penehyclidine hydrochloride group and atropine group,20 cases each.40 cases were administered narcotic ketamine MAP,HR and SpO2 were observed.Results The sedative effects and mental reaction after anesthesizing were not markedly differences in the two groups (P>0.05).In atropine group,HR was increased markedly (P<0.01).HR and MAP were unchanged in penehyclidine hydrochloride group.In atropine group,HR was increased,MAP was elevated after narcotic ketamine administering.And in penehyclidine hydrochloride group,HR and MAP were increased slightly (P>0.05).Conclusion The remedy in this study is a well medication pre-anesthesizing in children to maintain HR and MAP and to decrease mental reaction in the wakening period. ......