[摘要] 目的 探讨2型糖尿病肾病(DN)患者血清中一氧化氮、肿瘤坏死因子水平及其临床意义。方法 检测70例2型糖尿病患者血清一氧化氮(NO)和肿瘤坏死因子α(TNF-α)的水平。结果 单纯糖尿病患者和隐性糖尿病肾病患者血清NO水平较对照组明显升高，而糖尿病肾病患者血清NO水平较对照组明显减少。2型糖尿病患者各组TNF-α水平较对照组明显升高，其中ODN组最高。糖尿病肾病患者血清NO与TNF-α呈高度负相关关系。结论 NO和TNF-α可能参与2型糖尿病肾病的发病及病理变化过程，检测患者NO和TNF-α水平可作为判断预后、指导治疗的指标。

    [关键词] 2型糖尿病肾病；肿瘤坏死因子α；一氧化氮

    Levels and clinical significance of serum tumor necrosis factoralpha,nitric oxide in patients with type 2 diabetic nephropathy

    LI Xu-guang，ZHANG Jing,LI Shi-mei.The 323th Hospital of PLA ,Xi'an 710054, China

    [Abstract] Objective To explore the levels and clinical significance of TNF-α, NO in the patients with type 2 diabetic nephropathy.Methods The levels of TNF-α were measured by ELISA in 70 patients with T2DN. The levels of NO were measured by nitrate reduction test.Results The levels of TNF-α in the patients with T2DN were markedly higher than those of the normal group (P<0.01), but the levels of NO were lower than those of normal group (P<0.01). There was a negative correlation between TNF-α and NO in the patients with overt diabetic nephropathy.Conclusion TNF-α, NO are involved in the process of T2DN and closely related to the activity. Testing the levels of TNF-α, NO are helpful to observe the activity of the disease and the clinical curative effects of drugs ......