瘦素受体与核转录因子-κB在结直肠腺癌组织中的表达及意义
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熊枝繁, 晏泽辉
瘦素受体;核转录因子-kB;结直肠腺癌熊枝繁,晏泽辉.瘦素受体与核转录因子-kB在结直肠腺癌组织中的表达及意义. 世界华人消化杂志2006;14(28)2759-2764,瘦素受体与核转录
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熊枝繁, 晏泽辉, 华中科技大学同济医学院附属梨园医院消化内科 湖北省武汉市 430077
熊枝繁, 1999年武汉大学医学院硕士, 教授, 硕士生导师, 主要从事消化道肿瘤研究.湖北省自然科学基金资助项目, No. 2006ABA136
通讯作者: 熊枝繁, 430077, 湖北省武汉市, 华中科技大学同济医学院附属梨园医院消化内科. xiongzhifan@126.com
电话: 027-86777592
收稿日期: 2006-08-01 接受日期: 2006-08-23
Expression of leptin receptor and nuclear factor kappa B and their significances in colorectal adenocarcinoma
Zhi-Fan Xiong, Ze-Hui Yan
Zhi-Fan Xiong, Ze-Hui Yan, Department of Digestive Diseases, Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, 430077 Wuhan, Hubei Province, China
Supported by the Natural Science Foundation of Hubei Province, No. 2006ABA136
Correspondence to: Dr. Zhi-Fan Xiong, Department of Digestive Diseases, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430077 Wuhan, Hubei Province,China. xiongzhifan@126.com
Received: 2006-08-01Accepted: 2006-08-23
AbstractAIM:To investigate the expression of leptin receptor (Ob-R) in colorectal adenocarcinoma, and explore its role in the tumor angiogenesis and the possible mechanism.
METHODS:Immumohistochemical staining was performed to detect the expression of Ob-R, CD105, and nuclear factor-kappa B p65 (NF-kBp65) in colorectal adenocarcinoma (n = 35), colorectal adenoma (n = 24) and normal controls (n = 35). Image analysis software was used for semi-quantitative assessment.
RESULTS:The microvessel density (MVD) marked by CD105 was decreased progressively from cancer patients, adenoma patients and normal controls (23.63 ± 2.08 vs 10.83 ± 1.25 vs 1.97 ± 0.37, P < 0.05). Ob-R and NF-kBp65 were expressed at the similar location. The integrated optical densities of Ob-R and NF-kBp65 in cancer patients were both higher than those in the normal controls (27.41 ± 2.21 vs 20.45 ± 1.63, P < 0.05; 45.88 ± 5.46 vs 29 ......
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