大肠癌免疫组化表达与临床病理的关系
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顾国利, 任 力, 黄蓉蓉, 魏学明, 李德昌,
大肠癌;癌胚抗原;P53;转移抑制基因;细胞增殖相关核抗原;多药耐药相关蛋白;病理;免疫组化顾国利,任力,黄蓉蓉,魏学明,李德昌,戴大江,王石林.大肠癌免疫组化表达与临床病理的关系. 世界
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顾国利, 黄蓉蓉, 魏学明, 戴大江, 王石林, 中国人民解放军空军总医院普通外科 北京市 100036
任力, 李德昌, 中国人民解放军空军总医院病理科 北京市 100036
顾国利, 2004年中国医科大学硕士, 主治医师, 讲师, 主要从事普外科临床肿瘤学的研究.
通讯作者: 王石林, 100036, 北京市, 中国人民解放军空军总医院普通外科. wangshilin@medmail.com.cn
电话: 010-68410099-6302
收稿日期: 2006-08-19 接受日期: 2006-09-12
Immunohistochemical expression of carcinoembryonic antigen, P53, nm23, Ki-67, multidrug resistance-associated protein and their correlations with the clinicopathology in colorectal carcinoma
Guo-Li Gu, Li Ren, Rong-Rong Huang, Xue-Ming Wei, De-Chang Li, Da-Jiang Dai, Shi-Lin Wang
Guo-Li Gu, Rong-Rong Huang, Xue-Ming Wei, Da-Jiang Dai, Shi-Lin Wang, Department of General Surgery, General Hospital of Chinese PLA Air force, Beijing 100036, China
Li Ren, De-Chang Li, Department of pathology, General Hospital of Air force PLA, 100036 Beijing, China
Correspondence to: Shi-Lin Wang, Department of General Surgery, General Hospital of Chinese PLA Air Force, Beijing 100036, China. wangshilin@medmail.com.cn
Received: 2006-08-19Accepted: 2006-09-12
AbstractAIM:To investigate the mechanism of cyclooxygenase-2 (COX-2), basic fibroblast growth factor (bFGF) in the carcinogenesis of colorectal carcinoma and adenoma.
METHODS:The expression of CEA, P53, nm23, Ki-67 and MRP protein were detected by SP immunohistochemistry in colorectal carcinoma (n= 73) admitted from January 2003 to July 2006, and their clinical data and follow-up documents were analyzed retrospectively.
RESULTS:The positive rates of CEA, P53, nm23, Ki-67 and MRP protein expression in colorectal cancer were 82.2%, 68.5%, 75.3%, 84.9% and 64.4%, respectively. CEA and MRP expression had no correlations with the patients’ages, sex, tumor size or location and differentiation types of tumor, depth of invasion and lymph node metastasis, while P53, Ki-67 and nm23 expression were significantly correlated with the depth of invasion and lymph node metastasis ......
顾国利, 黄蓉蓉, 魏学明, 戴大江, 王石林, 中国人民解放军空军总医院普通外科 北京市 100036
任力, 李德昌, 中国人民解放军空军总医院病理科 北京市 100036
顾国利, 2004年中国医科大学硕士, 主治医师, 讲师, 主要从事普外科临床肿瘤学的研究.
通讯作者: 王石林, 100036, 北京市, 中国人民解放军空军总医院普通外科. wangshilin@medmail.com.cn
电话: 010-68410099-6302
收稿日期: 2006-08-19 接受日期: 2006-09-12
Immunohistochemical expression of carcinoembryonic antigen, P53, nm23, Ki-67, multidrug resistance-associated protein and their correlations with the clinicopathology in colorectal carcinoma
Guo-Li Gu, Li Ren, Rong-Rong Huang, Xue-Ming Wei, De-Chang Li, Da-Jiang Dai, Shi-Lin Wang
Guo-Li Gu, Rong-Rong Huang, Xue-Ming Wei, Da-Jiang Dai, Shi-Lin Wang, Department of General Surgery, General Hospital of Chinese PLA Air force, Beijing 100036, China
Li Ren, De-Chang Li, Department of pathology, General Hospital of Air force PLA, 100036 Beijing, China
Correspondence to: Shi-Lin Wang, Department of General Surgery, General Hospital of Chinese PLA Air Force, Beijing 100036, China. wangshilin@medmail.com.cn
Received: 2006-08-19Accepted: 2006-09-12
AbstractAIM:To investigate the mechanism of cyclooxygenase-2 (COX-2), basic fibroblast growth factor (bFGF) in the carcinogenesis of colorectal carcinoma and adenoma.
METHODS:The expression of CEA, P53, nm23, Ki-67 and MRP protein were detected by SP immunohistochemistry in colorectal carcinoma (n= 73) admitted from January 2003 to July 2006, and their clinical data and follow-up documents were analyzed retrospectively.
RESULTS:The positive rates of CEA, P53, nm23, Ki-67 and MRP protein expression in colorectal cancer were 82.2%, 68.5%, 75.3%, 84.9% and 64.4%, respectively. CEA and MRP expression had no correlations with the patients’ages, sex, tumor size or location and differentiation types of tumor, depth of invasion and lymph node metastasis, while P53, Ki-67 and nm23 expression were significantly correlated with the depth of invasion and lymph node metastasis ......
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