不同给药途径对大鼠溃疡性结肠炎结肠黏膜EGF表达的影响
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王雪茜, 王新月, 杨莉莉
溃结饮;表皮生长因子;溃疡性结肠炎;大鼠,王雪茜,王新月,杨莉莉,通讯作者:,Effectsofdifferentadministrati
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王雪茜, 王新月, 杨莉莉, 北京中医药大学东直门医院 北京市 100700 国家自然科学基金资助项目, No. 30572390
国家中医药管理局中医药科学技术研究基金资助项目, 国中医药科02-03GP03
通讯作者: 王新月, 100700, 北京市东城区海运仓5号, 北京中医药大学东直门医院. wxy6687@sina.com
电话: 010-84013361
收稿日期: 2006-05-19 接受日期: 2006-06-30
Effects of different administration approaches on expression of epidermal growth factor after in rats with ulcerative colitis
Xue-Qian Wang, Xin-Yue Wang, Li-Li Yang
Xue-Qian Wang, Xin-Yue Wang, Li-Li Yang,Dongzhimen Hospital affiliated to Beijing University of Traditional Chinese Medicine, Beijing 100700, China
Supported byNational Natural Science Foundation of China, No. 30572390, and State Administration of Chinese Medicine Science and Technology Foundation of China, National Chinese Medicine Department 02-03GP03
Correspondence to:Dr. Xin-Yue Wang, Dongzhimen Hospital affiliated to Beijing University of Traditional Chinese Medicine, 5 Haiyuncang, Dongcheng District, Beijing 100700, China. wxy6687@sina.com
Received:2006-05-19 Accepted:2006-06-30
Abstract
AIM: To observe the effects of Kui Jieyin given in different ways on the expression of mucosal epidermal growth factor (EGF) in the rectum and colon of rats with ulcerative colitis (UC), and explore a better method for the treatment of UC.
METHODS: The UC rat model was induced by intermixture of TNBS and ethanol. All the rats were divided into 5 groups. Normal group (n = 15) and model group (n = 15) were given distilled water. The rest rats were intragastrically administered with olsalazine sodium (group A) or Kui Jieyin (group B), or treated with Kui Jieyin enema (group C). Then the expression of rectal and colonic mucosal EGF was detected by immunohisthchemical staining.
RESULTS: After drugs interference, the expression of colonic mucosal EGF in UC was increased, especially in group B and C. For the active UC, the expression of EGF was higher in group B than that in group C (no significance) or A (0 ......
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