农村居民家庭幽门螺杆菌感染的血清流行病学调查
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范红敏, 袁聚祥, 徐应军, 张天哲
农村居民;螺杆菌;幽门;家庭聚集性;血清流行病学;Westernblot范红敏,袁聚祥,徐应军,张天哲.农村居民家庭幽门螺杆菌感染的血清流行病学调查. 世界华人消化杂志2006;14(30
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范红敏, 袁聚祥, 徐应军, 张天哲, 华北煤炭医学院预防医学系 河北省唐山市 063000
范红敏, 2000年华北煤炭医学院硕士研究生毕业, 现今中国协和医科大学在读博士研究生, 讲师, 主要从事传染病流行病学研究.
通讯作者: 范红敏, 063000, 河北省唐山市建设南路57号, 华北煤炭医学院预防医学系. fhm01@sohu.com
电话: 0315-3725719 传真: 0315-3725312
收稿日期: 2006-08-01 接受日期: 2006-08-15
A seroepidemiology survey on Helicobacter pylori infection in rural families
Hong-Min Fan, Ju-Xiang Yuan, Ying-Jun Xu, Tian-Zhe Zhang
Hong-Min Fan, Ju-Xiang Yuan, Ying-Jun Xu, Tian-Zhe Zhang, Department of Preventive Medicine, North China Coal Medical College, Tangshan 063000, Hebei Province, China
Correspondence to: Hong-Min Fan, Department of Preventive Medicine, North China Coal Medical College, 57 Jianshe North Road, Tangshan 063000, Hebei Province, China. fhm01@sohu.com
Received: 2006-08-01 Accepted: 2006-08-15
Abstract
AIM:To estimate the prevalence of H pylori infection in rural families, and to investigate the transmission route of H pylori infection.
METHODS: A cross-sectional study was carried out among 263 villagers from 71 families in September 2004 in Zunhua city, Hebei province. Each subject was interviewed using a unified questionnaire. Blood sample of 5 mL was collected for the antibody examination by enzyme-linked immunosorbent assay (ELISA). Western blot analysis was performed to distinguish the infected strains, and compared with two standard strains NCTC 11637 and CAPM N111, respectively. Similarity analysis was then carried out with Quantity one 4.1.1 software, which is special for photographs of electrophoresis.
RESULTS: The seroprevalence of H pylori infection in residents of this area was of medium level in our country, and it was not associated with gender. In this area, the risk factors of infection were bad living conditions, overcrowding and possession of pigs during childhood, as well as several generations eating together, less vinegar and fruit intake ......
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