Changes of HPV DNA and TNFª²¦Á levels in patients with advanced cervical cancer before and after concurrent chemoradiotherapy

    ZENG Siª²Yuan, LI Longª²Yu, LI Hanª²Ping

    Department of Gynecologic Oncology, Maternal and Child Health Hospital of Jiangxi Province, Nanchang 330006, China

    ¡¾Abstract¡¿ AIM: To analyze the changing of HPV DNA in cervical secretions and serum TNFª²¦Á level in patients with advanced cervical cancer before and after concurrent chemoradiotherapy. METHODS: The level of HPV DNA was tested by HCª²2 and TNFª²¦Á by ABCª²ELISA in 30 patients with advanced cervical cancer(reseach group) before and after chemoradiotherapy and 20 healthy women as the controls. RESULTS: The HPV infection rate before treatment(96.7%) was higher than that after treatment (20%) and in normal controls(10%). The negative conversion rate at the end of treatment was 79.3%(23/29). The levels of serum TNFª²¦Á before and after chemoradiotherapy [(134.15¡À77.99) and (113.14¡À79.99) pg/mL respectively]were both higher than that in normal controls[(54.91¡À13.19) pg/mL, P<0.01]. Serum TNFª²¦Á levels had no significant difference between preª²treatment and postª²treatment (P>0.05), but a tendency of decreasing existed. CONCLUSION: The detection of HPV DNA in cervical secreations and serum TNFª²¦Á might be useful reference indexes for diagnosis and judging prognosis or curative effect. ......