Expressions and significances of cathepsin D and Eª²selectin in nasal NK/T cell lymphoma

    WANG Juanª²Hong, HUANG Gaoª²Sheng, WANG Zhe, FENG Jiª²Liang, YANG Guoª²Rong, GUO Ying

    Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To explore the expressions and significances of cathepsin D (CD) and Eª²selectin in the newly recognized nasal NK/T cell lymphoma. METHODS: Immunohistochemical SP method was used in 41 cases of nasal nonª²Hodgkin¬ð s lymphoma to examine the expressions of CD45RO, CD3¦Å, CD20, CD79¦Á, CD56 and TIAª²1; In situ hybridization for EBER1/2 (EBERª²ISH) was used to examine Epsteinª²Barr virus (EBV) infection. As a result, 21 cases of nasal NK/T cell lymphoma were diagnosed according to the newly published WHO standard. The expressions of CD and Eª²selectin were detected immunohistochemically in the 21 cases of nasal NK/T cell lymphoma and 10 cases of lymphoid hyperplasia. RESULTS: CD was expressed intensively in plasma of scattered stromal histiocytes and the positive signal of CD in nasal NK/T cell lymphoma was much stronger than that in lymphoid hyperplasia (t=39.12, P£½0.000). The positive signal of Eª²selectin was expressed in vascular endothelium and the mean positive rates of the 2 groups had no significant difference statistically(t=0.688, P£½0.497). CONCLUSION: The higher expression of CD in the stroma of nasal NK/T cell lymphoma may relate to the high aggressiveness of nasal NK/T cell lymphoma, while Eª²selectin may have no intimate correlation with it. ......