Distribution of 99mTcª²TRODATª²1 in brain of rats with Parkinson¬ðs disease

    DU Mingª²Hua, JIA Peng, WANG Xiª²Hai, LIU Siª²Ming, JU Shengª²Hong

    Department of Nuclear Medicine, Department of Neurosurgery, Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China

    ¡¾Abstract¡¿ AIM: To develop 99mTc labeled dopamine transporter (DAT) imaging agent 99mTcª²(2¦Âª² [N, N, ª²bis(2ª²mercaptoethyl)ethylenediamino]methyl, 3¦Âª²(4ª²chlorophenyl)tropane (TRODATª²1) for evaluating the changes of DAT in rat models with Parkinson¬ðs Disease(PD). METHODS: A total of 40 SD rats were randomly divided into 3 groups: control group (n=14), unilateral PD models (n=14) and multiple cerebral infarction models by injecting autothrombus into carotid artery (n=12). 99mTcª²TRODATª²1 distribution in normal rat striatum was observed. The uptake rates of 99mTcª²TRODATª²1 in healthy side and injured side of PD rat striatum and in two sides of multiple infarction rat striatum were compared. RESULTS: 99mTcª²TRODATª²1 distribution in normal rat brain and striatum exhibited an obvious uptake of 99mTcª²TRODATª²1 in striatum. In PD rats, the uptake was less in injured striatum than that in normal striatum obviously. The uptake rate of multiple infarction rat was similar with that of normal rats. CONCLUSION: 99mTcª²TRODATª²1 might be uptaken specificly by rat striatum, so its imaging can provide a beneficial evidence for the early diagnosis of PD. ......