【摘要】 以CH3OH-NH3溶液为溶剂，用费休氏法测定奥柳氮锌中的水分。方法快速，结果准确，对类似有机金属药物中水分的测定有所借鉴。

    【关键词】 奥柳氮锌；CH3OH-NH3溶液；费休氏法；水分；测定

    【Abstract】 Karl Fischer titration was applied to determine the water in olsalazine zinc，using methanol-ammonia as the solvent.The result showed that it was superior to the normal method.The water content determination has the model to the similar organic metal medicine.

    【Key words】 olsalazine zinc；methanol-ammonia solution；Karl Fischer titration；water；determination

    奥柳氮锌(olsalazine zinc)是一种治疗溃疡性肠炎和结肠炎的理想药物，在结肠部位经细菌裂解为二分子活性成分5-氨基水杨酸，在锌离子的协同作用下，可抑制引起炎症的前列腺合成 ......