慢性幽门螺旋杆菌感染、血清TNFα变化与脑梗死相关研究
幽门螺旋杆菌;脑梗死;危险因素;13C尿素呼气实验;TNFα,,幽门螺旋杆菌;脑梗死;危险因素;13C尿素呼气实验;TNFα,1
【摘要】目的: 检测血清中TNFα含量的变化,用以研究慢性幽门螺旋杆菌(Helicobacter pylori, Hp)感染与脑梗死的关系。 方法: 采用病例对照的研究方法,选择急性脑梗死患者65例为病例组,健康体检者50例为对照组。用13C尿素呼气实验检测Hp感染,用酶联免疫吸附法定量检测血清中TNFα的含量。 结果: ①病例组与对照组的Hp阳性率分别是323%和140%,病例组明显高于对照组,两组比较有统计学意义;②28例Hp阳性者血清中TNFα的含量平均值2008±882pg/ml。87例Hp阴性者是1507±530pg/ml,Hp阳性组明显高于Hp阴性组,两组比较有统计学意义。 结论: 慢性Hp感染是急性脑梗死的一个危险因素,慢性Hp感染可引起血清中TNFα的含量增高,后者是导致急性脑梗死的发病机制之一。【关键词】幽门螺旋杆菌;脑梗死;危险因素;13C尿素呼气实验;TNFα
Study on the Relationship between Chronic Helicobacter pylori Infection、
Changes of TNFα Levels in Serum and Acute Cerebral Infarction
YU Aimei, ZOU Yuan
Department of Neurology, the First Affiliated Hospital,
Hebei North University, Zhangjiakou, 075000, Hebei China
【ABSTRACT】Objective: To study the relationship between chronic Helicobacter pylori(Hp) infection and acute cerebral infarction by testing the changes of TNFα in the serum.Methods: By the casecontrol study, 65 cases with acute cerebral infarction(patients group) and 50 healthy persons (control group) were selected. ......
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