脂蛋白类_LDL；C反应蛋白；心绞痛_

心绞痛患者氧化型低密度脂蛋白自身抗体和C反应蛋白的检测及临床意义

http://www.100md.com 《广东药学院学报》 2006年第2期

脂蛋白类,LDL；C反应蛋白；心绞痛,,脂蛋白类，LDL；C反应蛋白；心绞痛,1资料与方法,2结果,3讨论,参考文献：

     【摘要】目的：观察心绞痛(AP)患者血清氧化型低密度脂蛋白自身抗体(AbOXLDL)和C反应蛋白(CRP)的浓度变化及其与心绞痛类型的关系。方法：将符合AP诊断的72例患者分为不稳定型心绞痛(UAP)组(n=35)和稳定型心绞痛(SAP)组(n=37)，另选健康体检者为对照组(n=35)。采用酶联免疫吸附法测定血清AbOXLDL与CRP浓度。结果： AbOXLDL与CRP浓度，UAP组均显著高于SAP组和对照组(P<0.01)，SAP组显著高于对照组(P<0.01)。AbOXLDL与CRP在UAP组呈高度正相关(r=0.713,P<0.01)，SAP组也呈高度正相关(r=0.702,P<0.01)，对照组无相关(r=0.303,P>0.05)。结论：血清AbOXLDL与CRP浓度反映了心绞痛的类型，在评价缺血性心脏病病变程度方面有重要的参考价值。

    【关键词】脂蛋白类，LDL；C反应蛋白；心绞痛

    Measurement and clinical significance of the antibody against oxidized low density

    lipoprotein and the Creactive protein in patients with angina pectoris

    MAI Qi，BAI Man，YUAN Hanyao

    (The Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001，China)

    【Abstract】Objective：To measure the levels and observe the clinical significance of the antibody against oxidized low density lipoprotein (AbOXLDL) and the Creactive protein (CRP) in patients with angina pectoris (AP). Methods：The serous level of AbOXLDL and CRP were measured by the EnzymeLinked Immunosorbent Assay in Group UAP (unstable AP, 35 cases), Group SAP (stable AP, 37 cases) and the control group (healthy persons,35 cases). Results： Compared with the control group, the levels of both AbOXLDL and CRP markedly increased in AP patients (P< 0.01). The levels of both AbOXLDL and CRP were higher in UAP group than that in SAP group (P< 0.01). The increased level of both AbOXLDL and CRP positively correlated (r = 0.713, P <0.01). Conclusion：Serum concentrations of AbOXLDL and CRP reflect AP types, and could be valuable in the assessment of the severity of the AP. ......

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