半边旗；增生性瘢痕；动物模型_

半边旗5F对兔耳增生性瘢痕组织的影响

http://www.100md.com 《广东药学院学报》 2006年第2期

半边旗；增生性瘢痕；动物模型,,半边旗；增生性瘢痕；动物模型,1材料与方法,2结果,3讨论,参考文献:

     【摘要】目的：观察半边旗5F对兔耳增生性瘢痕组织的影响。方法：建立兔耳增生性瘢痕动物模型，21d时瘢痕局部注射不同浓度(20,40,80 mg/L)的半边旗5F或生理盐水，28d时观察药物对瘢痕增生指数(HI)的影响及光镜下瘢痕变化情况。结果：各浓度组与生理盐水对照组以及各浓度组之间HI差异均有显著性意义 (P<0.01)；其瘢痕抑制效果与半边旗5F浓度呈剂量依赖性关系；光镜下见明显抑制成纤维细胞增殖及降低胶原纤维的含量。结论：半边旗5F可抑制兔耳增生性瘢痕组织增生。

    【关键词】半边旗；增生性瘢痕；动物模型

    Effects of Pteris Semipinnata 5F on the hypertrophic scar on rabbit ears

    CHEN Ping，WU Zhiyuan，LUO Shaojun，TANG Shaomin, JIANG Limin

    (Department of Plastic Surgery, Guangdong Medical College，Zhanjiang 524001, China)

    【Abstract】 Objective: To observe the effects of Pteris Semipinnata 5F on the hypertrophic scar on rabbit ears. Methods: Hypertrophic scars made on rabbit ears were injected with Pteris Semipinnata 5F at concentrations (20, 40, 80mg/L) or saline as control at day 21 started from the scars were made. At day 28 the rabbits were killed to observe hypertrophic index (HI) and morphological change of scars. Results: Compared with the control group, Pteris Semipinnata 5F significantly reduced HI in a dosage dependent manner (P<0.05). The proliferation of fibroblast and collagen decreased in the Pteris Semipinnata 5F treated group. Conclusion: Pteris Semipinnata 5F could inhibit proliferation of hypertrophic scars on rabbit ears. ......

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