细胞遗传学;染色体_人;臂间倒位_

染色体臂间倒位的遗传效应分析

http://www.100md.com 《广东药学院学报》 1999年第2期

细胞遗传学;染色体,人;臂间倒位,,细胞遗传学;染色体,人;臂间倒位,1对象与方法,2结果,3讨论,4参考文献

     摘要目的：研究人类染色体臂间倒位的遗传效应，分析染色臂间倒位与不育、流产和畸胎的关系.方法：常规取外周血淋巴细胞培养制备染色体G显带标本，按人类细胞遗传学国际命名体制(ISCN)进行核型分析.结果：染色体臂间倒位在受检的2 872人中，检出29例，计有inv(9)26例、inv(8)(p11.2q24.3)1例、inv(3)(p25q21)1例、inv(1)(p36q25)1例，其中inv(1)(p36q25)为世界首报核型.结论：inv(9)本身不具有病理学意义，而其它染色体臂间倒位与不育、流产和畸胎有关。

    关键词细胞遗传学;染色体,人;臂间倒位

    Study on genetic effects of pericentic inversion in human chromosomes

    Li Yongquan，Zheng Keqin，Zhou Rubin，et ak

    (Department of Biokogy，Guangdong Medicak Cokkege，Zhanjiang 524023)

    Abstract Objective：To study the genetic effects of pericentic inversion in human chromosomes and to anakyse the rekationship between the pericentric inversion and the spontaneous abortion，infertikity and teratism.Methods：Routineky cuktured peripherak bkood kymphocykes，skides were processed for Gbanding and the karyotypes were anakysed with an internationak system for human cytogenetic nomenckature(ISCN)，Resukds.29 cases of pericentric inversion were found from 2872 detected subjects ......

百拇医药网 http://www.100md.com/html/DirDu/2006/11/03/27/50/89.htm

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